PMID- 27648169
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160920
LR  - 20201001
IS  - 1949-8470 (Print)
IS  - 1949-8470 (Electronic)
IS  - 1949-8470 (Linking)
VI  - 8
IP  - 8
DP  - 2016 Aug 28
TI  - Relative volume measured with magnetic resonance imaging is an articular collapse 
      predictor in hematological pediatric patients with femoral head osteonecrosis.
PG  - 750-6
LID - 10.4329/wjr.v8.i8.750 [doi]
AB  - AIM: To assess the potential value of femoral head (FH) volume measurements to 
      predict joint collapse, as compared to articular surface involvement, in 
      post-treatment osteonecrosis (ON) in pediatric patients affected by 
      lymphoproliferative diseases. METHODS: Considering 114 young patients with 
      lymphoproliferative diseases undergone a lower-limbs magnetic resonance imaging 
      (MRI) examination between November 2006 and August 2012 for a suspected 
      post-treatment ON, we finally considered a total of 13 cases (7 males, mean age 
      15.2 +/- 4.8 years), which developed a FH ON lesions (n = 23). The MRI protocol 
      included coronal short tau inversion recovery and T1-weighted sequences, from the 
      hips to the ankles. During the follow-up (elapsed time: 9.2 +/- 2 mo), 13/23 FH 
      articular surface (FHS) developed articular deformity. The first MRI studies with 
      diagnosis of ON were retrospectively analyzed, measuring FH volume (FHV), FHS, ON 
      volume (ONV) and the articular surface involved by ON (ONS). The relative 
      involvement of FHS, in terms of volume [relative volume (RV): ONV/FHV] and 
      articular surface [relative surface (RS): ONS/FHS], was then calculated. RESULTS: 
      By using receiver operating characteristic curve analysis (threshold of 23% of 
      volume involvement), RV predicted articular deformity in 13/13 FHS [sensitivity 
      100%, specificity 90%, accuracy 95%, positive predictive value (PPV) 93%, 
      negative predictive value (NPV) 100%]. Considering a threshold of 50% of 
      articular involvement, RS predicted articular deformity in 10/13 femoral heads 
      (sensitivity 77%, specificity 100%, accuracy 87%, PPV 100%, NPV 77%). CONCLUSION: 
      RV might be a more reliable parameter than RS in predicting FH deformity and 
      could represent a potential complementary diagnostic tool in the follow-up of 
      femoral heads ON lesions.
FAU - Ippolito, Davide
AU  - Ippolito D
AD  - Davide Ippolito, Alessandro Masetto, Cammillo Talei Franzesi, Pietro A Bonaffini, 
      Alessandra Casiraghi, Sandro Sironi, Department of Diagnostic Radiology, School 
      of Medicine, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, 
      Italy.
FAU - Masetto, Alessandro
AU  - Masetto A
AD  - Davide Ippolito, Alessandro Masetto, Cammillo Talei Franzesi, Pietro A Bonaffini, 
      Alessandra Casiraghi, Sandro Sironi, Department of Diagnostic Radiology, School 
      of Medicine, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, 
      Italy.
FAU - Talei Franzesi, Cammillo
AU  - Talei Franzesi C
AD  - Davide Ippolito, Alessandro Masetto, Cammillo Talei Franzesi, Pietro A Bonaffini, 
      Alessandra Casiraghi, Sandro Sironi, Department of Diagnostic Radiology, School 
      of Medicine, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, 
      Italy.
FAU - Bonaffini, Pietro A
AU  - Bonaffini PA
AD  - Davide Ippolito, Alessandro Masetto, Cammillo Talei Franzesi, Pietro A Bonaffini, 
      Alessandra Casiraghi, Sandro Sironi, Department of Diagnostic Radiology, School 
      of Medicine, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, 
      Italy.
FAU - Casiraghi, Alessandra
AU  - Casiraghi A
AD  - Davide Ippolito, Alessandro Masetto, Cammillo Talei Franzesi, Pietro A Bonaffini, 
      Alessandra Casiraghi, Sandro Sironi, Department of Diagnostic Radiology, School 
      of Medicine, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, 
      Italy.
FAU - Sironi, Sandro
AU  - Sironi S
AD  - Davide Ippolito, Alessandro Masetto, Cammillo Talei Franzesi, Pietro A Bonaffini, 
      Alessandra Casiraghi, Sandro Sironi, Department of Diagnostic Radiology, School 
      of Medicine, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, 
      Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Radiol
JT  - World journal of radiology
JID - 101538184
PMC - PMC5002506
OTO - NOTNLM
OT  - Articular surface
OT  - Femoral head
OT  - Lymphoproliferative diseases
OT  - Magnetic resonance imaging
OT  - Osteonecrosis
OT  - Volume
EDAT- 2016/09/21 06:00
MHDA- 2016/09/21 06:01
PMCR- 2016/08/28
CRDT- 2016/09/21 06:00
PHST- 2016/01/26 00:00 [received]
PHST- 2016/04/10 00:00 [revised]
PHST- 2016/05/31 00:00 [accepted]
PHST- 2016/09/21 06:00 [entrez]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2016/09/21 06:01 [medline]
PHST- 2016/08/28 00:00 [pmc-release]
AID - 10.4329/wjr.v8.i8.750 [doi]
PST - ppublish
SO  - World J Radiol. 2016 Aug 28;8(8):750-6. doi: 10.4329/wjr.v8.i8.750.