PMID- 27648638
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20170817
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 36
IP  - 12
DP  - 2016 Dec
TI  - LYSOPHOSPHATIDIC ACIDS AND AUTOTAXIN IN RETINAL VEIN OCCLUSION.
PG  - 2311-2318
AB  - PURPOSE: To analyze the levels of lysophosphatidic acids (LPAs) and autotaxin 
      (ATX) in undiluted vitreous of untreated patients with retinal vein occlusion 
      (RVO). METHODS: Sixty-four vitreous samples (40 RVO, 24 controls with idiopathic 
      floaters) were analyzed in this retrospective case series using LC/MS for LPAs 
      16:0, 18:0, 18:1, 20:4, and ELISA kits or Luminex technology for ATX, 
      angiopoetin-1 (ANG-1), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-8 
      (IL-8), monocyte chemoattractant protein-1 (MCP-1), pigment epithelium-derived 
      factor (PEDF), and vascular endothelial growth factor (VEGF). LPA and ATX levels 
      were correlated with the visual acuity, central macular thickness (CMT), average 
      retinal thickness (AvT), vitreal cytokine levels and with each other. RESULTS: 
      Levels of every LPA species tested and ATX were significantly increased in the 
      vitreous fluid from all patients with RVO (total LPAs: 968.0 +/- 842.3 nM; ATX: 2.5 
      +/- 1.02 nM) compared with controls (total LPAs: 225.2 +/- 292.8 nM, P < 0.0001; ATX: 
      1.9 +/- 1.00 nM, P = 0.005). There were strong positive correlations between the 
      vitreal levels of IL-6, IL-8, MCP-1, VEGF and LPAs. CONCLUSION: Levels of LPAs 
      and ATX were positively correlated with proinflammatory cytokines and VEGF and 
      might thus play an important role in the development of macular edema secondary 
      to RVO.
FAU - Dacheva, Ivanka
AU  - Dacheva I
AD  - *Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 
      daggerRoche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland; 
      double daggerDepartment of General Ophthalmology, Medical University of Lublin, Lublin, 
      Poland;  section signMedical Research Centre, Polish Academy of Science, Warsaw, Poland; 
       paragraph signDepartment of Ophthalmology, University of Freiburg, Freiburg, Germany; and 
      **Department of Ophthalmology, University of Southern California, Los Angeles, 
      California.
FAU - Ullmer, Christoph
AU  - Ullmer C
FAU - Ceglowska, Karolina
AU  - Ceglowska K
FAU - Nogoceke, Everson
AU  - Nogoceke E
FAU - Hartmann, Guido
AU  - Hartmann G
FAU - Muller, Stephan
AU  - Muller S
FAU - Rejdak, Robert
AU  - Rejdak R
FAU - Nowomiejska, Katarzyna
AU  - Nowomiejska K
FAU - Reich, Michael
AU  - Reich M
FAU - Nobl, Matthias
AU  - Nobl M
FAU - Tandogan, Tamer
AU  - Tandogan T
FAU - Kretz, Florian T A
AU  - Kretz FT
FAU - Auffarth, Gerd U
AU  - Auffarth GU
FAU - Koss, Michael J
AU  - Koss MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Cytokines)
RN  - 0 (Lysophospholipids)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.1.4.39 (alkylglycerophosphoethanolamine phosphodiesterase)
SB  - IM
MH  - Aged
MH  - Cytokines/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Lysophospholipids/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Phosphoric Diester Hydrolases/*metabolism
MH  - Retinal Vein Occlusion/*metabolism
MH  - Retrospective Studies
MH  - Vitreous Body/metabolism
EDAT- 2016/09/21 06:00
MHDA- 2017/06/27 06:00
CRDT- 2016/09/21 06:00
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2016/09/21 06:00 [entrez]
AID - 10.1097/IAE.0000000000001112 [doi]
PST - ppublish
SO  - Retina. 2016 Dec;36(12):2311-2318. doi: 10.1097/IAE.0000000000001112.