PMID- 27649063
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20220408
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 55
IP  - 6
DP  - 2017 Jun
TI  - Subcutaneous versus intravenous immunoglobulin for chronic autoimmune 
      neuropathies: A meta-analysis.
PG  - 802-809
LID - 10.1002/mus.25409 [doi]
AB  - INTRODUCTION: High-dose intravenous immunoglobulin (IVIg) is an evidence-based 
      treatment for multifocal motor neuropathy (MMN) and chronic inflammatory 
      demyelinating polyneuropathy (CIDP). Recently, subcutaneous immunoglobulin 
      (SC-Ig) has received increasing attention. METHODS: We performed a meta-analysis 
      of reports of efficacy and safety of SC-Ig versus IVIg for inflammatory 
      demyelinating polyneuropathies. RESULTS: A total of 8 studies comprising 138 
      patients (50 with MMN and 88 with chronic CIDP) were included in the 
      meta-analysis. There were no significant differences in muscle strength outcomes 
      in MMN and CIDP with Sc-Ig (MMN: effect size [ES] = 0.65, 95% confidence interval 
      [CI] = -0.31-1.61; CIDP: ES = 0.84, 95% CI = -0.01-1.69). Additionally SC-Ig had 
      a 28% reduction in relative risk (RR) of moderate and/or systemic adverse effects 
      (95% CI = 0.11-0.76). CONCLUSIONS: The efficacy of SC-Ig is similar to IVIg for 
      CIDP and MMN and has a significant safety profile. Muscle Nerve 55: 802-809, 
      2017.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Racosta, Juan M
AU  - Racosta JM
AD  - Department of Clinical Neurological Sciences, Room C7-131, University Hospital, 
      London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada, N6A 
      5A5.
AD  - Schulich School of Medicine & Dentistry, Western University, London, Ontario, 
      Canada.
FAU - Sposato, Luciano A
AU  - Sposato LA
AD  - Department of Clinical Neurological Sciences, Room C7-131, University Hospital, 
      London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada, N6A 
      5A5.
AD  - Schulich School of Medicine & Dentistry, Western University, London, Ontario, 
      Canada.
FAU - Kimpinski, Kurt
AU  - Kimpinski K
AD  - Department of Clinical Neurological Sciences, Room C7-131, University Hospital, 
      London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada, N6A 
      5A5.
AD  - Schulich School of Medicine & Dentistry, Western University, London, Ontario, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170209
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Immunoglobulins)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
CIN - Muscle Nerve. 2017 Jun;55(6):775-776. PMID: 28295417
MH  - *Administration, Cutaneous
MH  - Databases, Bibliographic/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Immunoglobulins/*administration & dosage
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Male
MH  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/*drug therapy
OTO - NOTNLM
OT  - CIDP
OT  - MMN
OT  - chronic inflammatory demyelinating polyneuropathy
OT  - immunoglobulin therapy
OT  - meta-analysis
OT  - multifocal motor neuropathy
EDAT- 2016/09/21 06:00
MHDA- 2017/08/18 06:00
CRDT- 2016/09/21 06:00
PHST- 2016/06/07 00:00 [received]
PHST- 2016/09/08 00:00 [revised]
PHST- 2016/09/14 00:00 [accepted]
PHST- 2016/09/21 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
PHST- 2016/09/21 06:00 [entrez]
AID - 10.1002/mus.25409 [doi]
PST - ppublish
SO  - Muscle Nerve. 2017 Jun;55(6):802-809. doi: 10.1002/mus.25409. Epub 2017 Feb 9.