PMID- 27652269
OWN - NLM
STAT- MEDLINE
DCOM- 20170118
LR  - 20181202
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2016
DP  - 2016
TI  - Synergistic Effect of Mesoporous Silica and Hydroxyapatite in Loaded 
      Poly(DL-lactic-co-glycolic acid) Microspheres on the Regeneration of Bone 
      Defects.
PG  - 9824827
LID - 10.1155/2016/9824827 [doi]
LID - 9824827
AB  - A microsphere composite made of poly(DL-lactic-co-glycolic acid) (PLGA), 
      mesoporous silica nanoparticle (MSN), and nanohydroxyapatite (nHA) (PLGA-MSN/nHA) 
      was prepared and evaluated as bone tissue engineering materials. The objective of 
      this study was to investigate the synergistic effect of MSN/nHA on 
      biocompatibility as well as its potential ability for bone formation. First, we 
      found that this PLGA-MSN/nHA composite performed good characteristics on 
      microstructure, mechanical strength, and wettability. By cell culture 
      experiments, the adhesion and proliferation rate of the cells seeded on 
      PLGA-MSN/nHA composite was higher than those of the controls and high levels of 
      osteogenetic factors such as ALP and Runx-2 were detected by reverse 
      transcriptase polymerase chain reaction. Finally, this PLGA-MSN/nHA composite was 
      implanted into the femur bone defect in a rabbit model, and its ability to induce 
      bone regeneration was observed by histological examinations. Twelve weeks after 
      implantation, the bone defects had significantly more formation of mature bone 
      and less residual materials than in the controls. These results demonstrate that 
      this PLGA-MSN/nHA composite, introducing both MSN and nHA into PLGA microspheres, 
      can improve the biocompatibility and osteoinductivity of composite in vitro and 
      in vivo and had potential application in bone regeneration.
FAU - He, Shu
AU  - He S
AUID- ORCID: 0000-0002-5696-1578
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Lin, Kai-Feng
AU  - Lin KF
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China; Department of Orthopaedics, Fuzhou General 
      Hospital of Nanjing Military Command, Fuzhou 350025, China.
FAU - Fan, Jun-Jun
AU  - Fan JJ
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Hu, Gang
AU  - Hu G
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Dong, Xin
AU  - Dong X
AD  - Department of Orthopaedics, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an 710038, China.
FAU - Zhao, Yi-Nan
AU  - Zhao YN
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Song, Yue
AU  - Song Y
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Guo, Zhong-Shang
AU  - Guo ZS
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Bi, Long
AU  - Bi L
AUID- ORCID: 0000-0002-9854-9338
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Liu, Jian
AU  - Liu J
AUID- ORCID: 0000-0002-7245-0671
AD  - Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical 
      University, Xi'an 710032, China.
LA  - eng
PT  - Journal Article
DEP - 20160829
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biocompatible Materials)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry/*therapeutic use
MH  - Bone Regeneration/*drug effects
MH  - Durapatite/chemistry/therapeutic use
MH  - Humans
MH  - Lactic Acid/chemistry/therapeutic use
MH  - *Microspheres
MH  - Polyglycolic Acid/chemistry/therapeutic use
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Rabbits
MH  - Silicon Dioxide/chemistry/therapeutic use
MH  - *Tissue Engineering
PMC - PMC5019907
EDAT- 2016/09/22 06:00
MHDA- 2017/01/19 06:00
PMCR- 2016/08/29
CRDT- 2016/09/22 06:00
PHST- 2016/01/27 00:00 [received]
PHST- 2016/06/26 00:00 [revised]
PHST- 2016/06/29 00:00 [accepted]
PHST- 2016/09/22 06:00 [entrez]
PHST- 2016/09/22 06:00 [pubmed]
PHST- 2017/01/19 06:00 [medline]
PHST- 2016/08/29 00:00 [pmc-release]
AID - 10.1155/2016/9824827 [doi]
PST - ppublish
SO  - Biomed Res Int. 2016;2016:9824827. doi: 10.1155/2016/9824827. Epub 2016 Aug 29.