PMID- 27652503
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20190225
IS  - 1759-4804 (Electronic)
IS  - 1759-4790 (Linking)
VI  - 12
IP  - 12
DP  - 2016 Dec
TI  - Altered dendritic cell functions in autoimmune diseases: distinct and overlapping 
      profiles.
PG  - 703-715
LID - 10.1038/nrrheum.2016.147 [doi]
AB  - Dendritic cells (DCs) are central regulators of the balance between immunity and 
      tolerance, and alteration of the specialized DC system is a common feature of 
      both systemic and tissue-specific autoimmune diseases. Increasing evidence 
      indicates that the heterogeneity and the remarkable functional diversity of DC 
      subsets might be differentially affected in autoimmune disorders, which accounts 
      for different pathologies. This Review discusses recent findings that support 
      this concept and provides a new conceptual overview of the altered function and 
      distribution of DCs in autoimmune disorders. The discussion will focus on 
      systemic lupus erythematosus - a prototype of a multi-organ disease - as well as 
      rheumatoid arthritis and idiopathic inflammatory myopathies, pathologies 
      characterized by tissue-specific lesions. Studies on these diseases have revealed 
      common and disease-specific changes in DC distribution and in critical DC 
      functions, such as phagocytosis, cytokine secretion and migration. An improved 
      understanding of the roles of altered DC distribution and/or disturbed key 
      functions in these autoimmune diseases will pave the way for the development of 
      new therapies aiming at reducing immunogenicity and at enhancing the tolerogenic 
      capacity of DCs. Although some tolerogenic DCs have already been introduced in 
      the clinic, the successful translation of other DC-based therapies will require 
      considerable research efforts.
FAU - Coutant, Frederic
AU  - Coutant F
AD  - Department of Immunobiology, University of Clermont Ferrand, Hopital Gabriel 
      Montpied, 58 rue de Montalembert, 630003 Clermont Ferrand, France.
FAU - Miossec, Pierre
AU  - Miossec P
AD  - Immunogenomics and Inflammation Research Unit EA 4130, Department of Clinical 
      Immunology and Rheumatology, University of Lyon, Hopital Edouard Herriot, 5 place 
      d'Arsonval, 69437 Lyon, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160922
PL  - United States
TA  - Nat Rev Rheumatol
JT  - Nature reviews. Rheumatology
JID - 101500080
RN  - 0 (Cytokines)
SB  - IM
MH  - Arthritis, Rheumatoid/*immunology/therapy
MH  - Autoimmune Diseases/immunology/therapy
MH  - Cell Movement/immunology
MH  - Cell- and Tissue-Based Therapy
MH  - Cytokines/immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Lupus Erythematosus, Systemic/*immunology/therapy
MH  - Myositis/*immunology
MH  - Phagocytosis/immunology
EDAT- 2016/11/05 06:00
MHDA- 2016/11/05 06:01
CRDT- 2016/09/23 06:00
PHST- 2016/11/05 06:00 [pubmed]
PHST- 2016/11/05 06:01 [medline]
PHST- 2016/09/23 06:00 [entrez]
AID - nrrheum.2016.147 [pii]
AID - 10.1038/nrrheum.2016.147 [doi]
PST - ppublish
SO  - Nat Rev Rheumatol. 2016 Dec;12(12):703-715. doi: 10.1038/nrrheum.2016.147. Epub 
      2016 Sep 22.