PMID- 27653661
OWN - NLM
STAT- MEDLINE
DCOM- 20161214
LR  - 20181202
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 38
IP  - 7
DP  - 2016
TI  - Relationship between cardio-ankle vascular index and homocysteine in hypertension 
      subjects with hyperhomocysteinemia.
PG  - 652-657
AB  - BACKGROUND: Arteriosclerosis evaluated by arterial stiffness is the basic 
      pathophysiological change during the development of hypertension. Cardio-ankle 
      vascular index (CAVI) is an index of arterial stiffness. Hyperhomocysteinemia 
      (HHcy) is an independent risk factor for vascular diseases. However, there was 
      little research about the relationship between CAVI and homocysteine (Hcy) in 
      hypertension subjects with HHcy. METHODS: A total of 330 subjects (M/F 133/197) 
      from Vascular Medicine of Peking University Shougang Hospital were divided into 
      four groups: control group (group 1, normotensive with normal Hcy, n = 149), 
      hypertension group (group 2, n = 113), HHcy group (group 3, n = 30), and 
      hypertension with HHcy group (group 4, n = 38). CAVI was measured by VS-1000 
      apparatus. RESULTS: Our results showed that CAVI was significantly higher in 
      group 4 than in group 1 and group 2 (8.41 +/- 1.08 vs. 7.79 +/- 1.14; 8.41 +/- 1.08 vs. 
      7.87 +/- 1.02, both p < 0.05, respectively). Positive correlation between CAVI and 
      Hcy was found in the entire study group (r = 0.109, p = 0.049) and hypertension 
      subjects (group 2 + group 4; r = 0.202, p = 0.014). Multivariate analysis showed 
      that Hcy was an independent associating factor of CAVI in all subjects (beta = 
      0.251, p = 0.034). CONCLUSIONS: The present study showed that CAVI was 
      significantly higher in hypertension subjects with HHcy compared to hypertension 
      group. There was significant correlation between CAVI and Hcy, indicating the 
      relationship between arterial stiffness and biomarkers in vascular-related 
      diseases.
FAU - Liu, Jinbo
AU  - Liu J
AD  - a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing 
      , P. R. of China.
FAU - Liu, Huan
AU  - Liu H
AD  - a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing 
      , P. R. of China.
FAU - Zhao, Hongwei
AU  - Zhao H
AD  - a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing 
      , P. R. of China.
FAU - Zhou, Yingyan
AU  - Zhou Y
AD  - a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing 
      , P. R. of China.
FAU - Li, Lihong
AU  - Li L
AD  - a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing 
      , P. R. of China.
FAU - Wang, Hongyu
AU  - Wang H
AD  - a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing 
      , P. R. of China.
LA  - eng
PT  - Journal Article
DEP - 20160921
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged, 80 and over
MH  - Ankle/blood supply
MH  - Biomarkers/blood
MH  - Blood Pressure/physiology
MH  - Blood Pressure Determination/*methods
MH  - China
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - *Hyperhomocysteinemia/blood/complications
MH  - *Hypertension/complications/metabolism/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Pulse Wave Analysis/*methods
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Statistics as Topic
MH  - Vascular Stiffness/*physiology
OTO - NOTNLM
OT  - Arterial function
OT  - cardio-ankle vascular index
OT  - hyperhomocysteinemia
OT  - hypertension
OT  - hypertension complications
EDAT- 2016/09/23 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/09/23 06:00
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/09/23 06:00 [entrez]
AID - 10.1080/10641963.2016.1182183 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2016;38(7):652-657. doi: 10.1080/10641963.2016.1182183. Epub 
      2016 Sep 21.