PMID- 27654278
OWN - NLM
STAT- MEDLINE
DCOM- 20170608
LR  - 20181202
IS  - 2168-6211 (Electronic)
IS  - 2168-6203 (Linking)
VI  - 170
IP  - 11
DP  - 2016 Nov 1
TI  - Association of Peripheral Blood Levels of Brain-Derived Neurotrophic Factor With 
      Autism Spectrum Disorder in Children: A Systematic Review and Meta-analysis.
PG  - 1079-1086
LID - 10.1001/jamapediatrics.2016.1626 [doi]
AB  - IMPORTANCE: Accumulating evidence suggests that brain-derived neurotrophic factor 
      (BDNF) may be implicated in the developmental outcomes of children with autism 
      spectrum disorder (ASD). OBJECTIVE: To use meta-analysis to determine whether 
      children with ASD have altered peripheral blood levels of BDNF. DATA SOURCE: A 
      systematic search of PubMed, PsycINFO, and Web of Science was performed for 
      English-language literature through February 7, 2016. The search terms included 
      brain-derived neurotrophic factor or BDNF in combination with autism, without 
      year restriction. Two additional records were retrieved after a review of the 
      reference lists of selected articles. STUDY SELECTION: Studies were included if 
      they provided data on peripheral blood levels of BDNF in children with ASD and 
      healthy control children. Studies that included adults or with overlapping 
      samples were excluded. DATA EXTRACTION AND SYNTHESIS: Data were extracted by 2 
      independent observers from 19 included studies. Data were pooled using a 
      random-effects model with Comprehensive Meta-analysis software. MAIN OUTCOMES AND 
      MEASURES: Blood levels of BDNF in children with ASD compared with healthy 
      controls. Altered levels of BDNF were hypothesized to be related to ASD. RESULTS: 
      This meta-analysis included 19 studies with 2896 unique participants. 
      Random-effects meta-analysis of all 19 studies showed that children with ASD had 
      significantly increased peripheral blood levels of BDNF compared with healthy 
      controls (Hedges g, 0.490; 95% CI, 0.185-0.794; P = .002). Subgroup analyses in 4 
      studies revealed that neonates diagnosed with ASD later in life had no 
      association with blood levels of BDNF (Hedges g, 0.384; 95% CI, -0.244 to 1.011; 
      P = .23), whereas children in the nonneonate ASD group (15 studies) demonstrated 
      significantly increased BDNF levels compared with healthy controls (Hedges g, 
      0.524; 95% CI, 0.206 to 0.842; P = .001). Further analysis showed that children 
      in the nonneonate ASD group had increased BDNF levels in serum (10 studies) 
      (Hedges g, 0.564; 95% CI, 0.168 to 0.960; P = .005) but not in plasma (5 studies) 
      (Hedges g, 0.436; 95% CI, -0.176 to 1.048; P = .16). Meta-regression analyses 
      revealed that sample size had a moderating effect on the outcome of the 
      meta-analysis in the nonneonate group. In addition, no publication bias was found 
      in the meta-analysis. CONCLUSIONS AND RELEVANCE: Children with ASD have increased 
      peripheral blood levels of BDNF, strengthening the clinical evidence of an 
      abnormal neurotrophic factor profile in this population.
FAU - Qin, Xiao-Yan
AU  - Qin XY
AD  - Center on Translational Neuroscience, College of Life and Environmental Sciences, 
      Minzu University of China, Beijing2Beijing Engineering Research Center of Food 
      Environment and Health, Minzu University of China, Beijing.
FAU - Feng, Jin-Chao
AU  - Feng JC
AD  - Center on Translational Neuroscience, College of Life and Environmental Sciences, 
      Minzu University of China, Beijing.
FAU - Cao, Chang
AU  - Cao C
AD  - Center on Translational Neuroscience, College of Life and Environmental Sciences, 
      Minzu University of China, Beijing.
FAU - Wu, Huan-Tong
AU  - Wu HT
AD  - Center on Translational Neuroscience, College of Life and Environmental Sciences, 
      Minzu University of China, Beijing.
FAU - Loh, Y Peng
AU  - Loh YP
AD  - Section on Cellular Neurobiology, Eunice Kennedy Shriver National Institute of 
      Child Health and Human Development, National Institutes of Health, Bethesda, 
      Maryland.
FAU - Cheng, Yong
AU  - Cheng Y
AD  - Section on Cellular Neurobiology, Eunice Kennedy Shriver National Institute of 
      Child Health and Human Development, National Institutes of Health, Bethesda, 
      Maryland.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - JAMA Pediatr
JT  - JAMA pediatrics
JID - 101589544
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
CIN - JAMA Pediatr. 2017 May 1;171(5):493. PMID: 28264085
CIN - JAMA Pediatr. 2017 May 1;171(5):492-493. PMID: 28264093
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child Development Disorders, Pervasive/*blood/metabolism
MH  - *Health Status
MH  - Humans
MH  - Reference Values
EDAT- 2016/09/23 06:00
MHDA- 2017/06/09 06:00
CRDT- 2016/09/23 06:00
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2017/06/09 06:00 [medline]
PHST- 2016/09/23 06:00 [entrez]
AID - 2553825 [pii]
AID - 10.1001/jamapediatrics.2016.1626 [doi]
PST - ppublish
SO  - JAMA Pediatr. 2016 Nov 1;170(11):1079-1086. doi: 
      10.1001/jamapediatrics.2016.1626.