PMID- 27655256
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20181113
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 41
IP  - 12
DP  - 2016 Dec
TI  - Intrathecal Injection of Human Umbilical Cord-Derived Mesenchymal Stem Cells 
      Ameliorates Neuropathic Pain in Rats.
PG  - 3250-3260
AB  - Neuropathic pain (NP) is a clinically incurable disease with miscellaneous 
      causes, complicated mechanisms and available therapies show poor curative effect. 
      Some recent studies have indicated that neuroinflammation plays a vital role in 
      the occurrence and promotion of NP and anti-inflammatory therapy has the 
      potential to relieve the pain. During the past decades, mesenchymal stem cells 
      (MSCs) with properties of multipotentiality, low immunogenicity and 
      anti-inflammatory activity have showed excellent therapeutic effects in cell 
      therapy from animal models to clinical application, thus aroused great attention. 
      However there are no reports about the effect of intrathecal human umbilical 
      cord-derived mesenchymal stem cells (HUC-MSCs) on NP which is induced by 
      peripheral nerve injury. Therefore, in this study, intrathecally transplanted 
      HUC-MSCs were utilized to examine the effect on neuropathic pain induced by a rat 
      model with spinal nerve ligation (SNL), so as to explore the possible mechanism 
      of those effects. As shown in the results, the HUC-MSCs transplantation obviously 
      ameliorated SNL-induced mechanical allodynia and thermal hyperalgesia, which was 
      related to the inhibiting process of neuroinflammation, including the suppression 
      of activated astrocytes and microglia, as well as the significant reduction of 
      pro-inflammatory cytokines Interleukin-1beta (IL-1beta) and Interleukin -17A (IL-17A) 
      and the up-regulation of anti-inflammatory cytokine Interleukin -10 (IL-10). 
      Therefore, through the effect on glial cells, pro-inflammatory and 
      anti-inflammatory cytokine, the targeting intrathecal HUC-MSCs may offer a novel 
      treatment strategy for NP.
FAU - Chen, Chunxiu
AU  - Chen C
AD  - Department of Anesthesiology, Institute of Anesthesiology and Critical Care 
      Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Chen, Fengfeng
AU  - Chen F
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, China.
FAU - Yao, Chengye
AU  - Yao C
AD  - Department of Anesthesiology, Institute of Anesthesiology and Critical Care 
      Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Shu, Shaofang
AU  - Shu S
AD  - Department of Anesthesiology, Institute of Anesthesiology and Critical Care 
      Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Feng, Juan
AU  - Feng J
AD  - Department of Anesthesiology, Institute of Anesthesiology and Critical Care 
      Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
AD  - Department of Anesthesia, The First Affiliated Hospital of University of South 
      China, Henyang, China.
FAU - Hu, Xiaoling
AU  - Hu X
AD  - Department of Anesthesia, The First Affiliated Hospital of University of South 
      China, Henyang, China.
FAU - Hai, Quan
AU  - Hai Q
AD  - Sichuan Province Regenerative Medicine Engineering Technology Research Center, 
      Chengdu, China.
FAU - Yao, Shanglong
AU  - Yao S
AD  - Department of Anesthesiology, Institute of Anesthesiology and Critical Care 
      Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Chen, Xiangdong
AU  - Chen X
AD  - Department of Anesthesiology, Institute of Anesthesiology and Critical Care 
      Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China. xiangdong_chen@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20160921
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-1beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Humans
MH  - Hyperalgesia/etiology/physiopathology/therapy
MH  - Inflammation/etiology/metabolism/therapy
MH  - Interleukin-10/metabolism
MH  - Interleukin-17/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Ligation
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Microglia/metabolism
MH  - Neuralgia/etiology/physiopathology/*therapy
MH  - Rats, Sprague-Dawley
MH  - Spinal Nerves/injuries
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - Astrocyte
OT  - Mesenchymal stem cells
OT  - Microglia
OT  - Neuropathic pain
OT  - Spinal nerve ligation
EDAT- 2016/09/23 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/09/23 06:00
PHST- 2016/04/19 00:00 [received]
PHST- 2016/08/27 00:00 [accepted]
PHST- 2016/08/23 00:00 [revised]
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/09/23 06:00 [entrez]
AID - 10.1007/s11064-016-2051-5 [pii]
AID - 10.1007/s11064-016-2051-5 [doi]
PST - ppublish
SO  - Neurochem Res. 2016 Dec;41(12):3250-3260. doi: 10.1007/s11064-016-2051-5. Epub 
      2016 Sep 21.