PMID- 27656567
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160922
LR  - 20231104
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 10
IP  - 8
DP  - 2016 Aug
TI  - Interlinking Periodontitis and Type 2 Diabetes Mellitus by Assessment of 
      Crevicular Visfatin Levels in Health and in Disease Before and After Initial 
      Periodontal Therapy.
PG  - ZC67-71
LID - 10.7860/JCDR/2016/18656.8283 [doi]
AB  - INTRODUCTION: Visfatin is a new adipocytokine associated with both chronic 
      periodontitis and type 2 diabetes mellitus independently. AIM: We aimed to 
      estimate and compare the changes in the levels of visfatin in the Gingival 
      Crevicular Fluid (GCF) of healthy subjects and in subjects with periodontitis 
      with or without controlled Type 2 Diabetes Mellitus (T2DM) after administration 
      of non-surgical periodontal therapy. MATERIALS AND METHODS: Forty two subjects 
      were equally divided into Group 1 (healthy), Group 2 (systemically healthy with 
      chronic periodontitis), Group 3 (subjects with chronic periodontitis having 
      controlled T2DM). Defined clinical parameters were recorded at baseline and at 
      one month follow-up period. Visfatin was assessed using enzyme linked 
      immunosorbent assay. One way ANOVA and Tukey's multiple post hoc procedures were 
      used. Pearson's correlation coefficient was used for correlation. RESULTS: 
      Significant increase in the visfatin levels was seen with the highest values 
      observed in diabetes with periodontal disease. Visfatin responded to non-surgical 
      periodontal therapy as observed by significant decrease in levels after one month 
      but even at this period diabetics showed the highest levels. CONCLUSION: Visfatin 
      levels are highest in individuals with both periodontal disease and diabetes even 
      after periodontal therapy. Individuals with T2DM may be at higher risk of 
      developing periodontal disease.
FAU - Mishra, Vandita
AU  - Mishra V
AD  - Senior Lecturer, Department of Periodontics, Sri Sai College of Dental Surgery , 
      Vikarabad, Telangana, India .
FAU - Shettar, Leena
AU  - Shettar L
AD  - Professor and Head, Department of Periodontics, S.D.M. College of Dental Sciences 
      and Hospital , Dharwad, Karnataka, India .
FAU - Bajaj, Mahesh
AU  - Bajaj M
AD  - Student, Department of Periodontics, SDM College of Dental Sciences and Hospital 
      , Dharwad, Karnataka, India .
FAU - Math, Abhishek Savir
AU  - Math AS
AD  - Reader, Department of Prosthodontics, Sri Sai College of Dental Surgery , 
      Vikarabad, Telangana, India .
FAU - Thakur, Srinath L
AU  - Thakur SL
AD  - Principal and Professor, Department of Periodontics, S.D.M. College of Dental 
      Sciences and Hospital , Dharwad, Karnataka, India .
LA  - eng
PT  - Journal Article
DEP - 20160801
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC5028447
OTO - NOTNLM
OT  - Adipokines
OT  - Biomarkers
OT  - Gingival crevicular fluid
OT  - Glycated haemoglobin
OT  - Periodontal disease
EDAT- 2016/09/23 06:00
MHDA- 2016/09/23 06:01
PMCR- 2016/10/01
CRDT- 2016/09/23 06:00
PHST- 2016/01/01 00:00 [received]
PHST- 2016/04/05 00:00 [accepted]
PHST- 2016/09/23 06:00 [entrez]
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2016/09/23 06:01 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2016/18656.8283 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2016 Aug;10(8):ZC67-71. doi: 10.7860/JCDR/2016/18656.8283. Epub 
      2016 Aug 1.