PMID- 27656624
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160922
LR  - 20201001
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 12
IP  - 4
DP  - 2016 Aug
TI  - Treadmill exercise facilitates recovery of locomotor function through axonal 
      regeneration following spinal cord injury in rats.
PG  - 284-92
LID - 10.12965/jer.1632698.349 [doi]
AB  - Spinal cord injury (SCI) disrupts both axonal pathways and segmental spinal cord 
      circuity, resulting in permanent neurological deficits. Physical exercise is 
      known to increase the expression of neurotrophins for improving the injured 
      spinal cord. In the present study, we investigated the effects of treadmill 
      exercise on locomotor function in relation with brain-derived neurotrophic factor 
      (BDNF) expression after SCI. The rats were divided into five groups: control 
      group, sham operation group, sham operation and exercise group, SCI group, and 
      SCI and exercise group. The laminectomy was performed at the T9-T10 level. The 
      exposed dorsal surface of the spinal cord received contusion injury (10 g x 25 
      mm) using the impactor. Treadmill exercise was performed 6 days per a week for 6 
      weeks. In order to evaluate the locomotor function of animals, 
      Basso-Beattie-Bresnahan (BBB) locomotor scale was conducted once a week for 6 
      weeks. We examined BDNF expression and axonal sprouting in the injury site of the 
      spinal cord using Western blot analysis and immunofluorescence staining. SCI 
      induced loss of locomotor function with decreased BDNF expression in the injury 
      site. Treadmill exercise increased the score of BBB locomotor scale and reduced 
      cavity formation in the injury site. BDNF expression and axonal sprouting within 
      the trabecula were further facilitated by treadmill exercise in SCI-exposed rats. 
      The present study provides the evidence that treadmill exercise may facilitate 
      recovery of locomotor function through axonal regeneration via BDNF expression 
      following SCI.
FAU - Jung, Sun-Young
AU  - Jung SY
AD  - Department of Physical Therapy, Hosan University, Gyeongsan, Korea.
FAU - Seo, Tae-Beom
AU  - Seo TB
AD  - Division of Sports Science and Engineering, Korea Institute of Sports Science, 
      Seoul, Korea.
FAU - Kim, Dae-Young
AU  - Kim DY
AD  - Department of Sports Health Care, College of Humanities & Social Sciences, Inje 
      University, Gimhae, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160831
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC5031384
OTO - NOTNLM
OT  - Axonal regeneration
OT  - Brain-derived neurotrophic factor
OT  - Locomotor function
OT  - Spinal cord injury
OT  - Treadmill exercise
EDAT- 2016/09/23 06:00
MHDA- 2016/09/23 06:01
PMCR- 2016/08/31
CRDT- 2016/09/23 06:00
PHST- 2016/06/27 00:00 [received]
PHST- 2016/07/31 00:00 [accepted]
PHST- 2016/09/23 06:00 [entrez]
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2016/09/23 06:01 [medline]
PHST- 2016/08/31 00:00 [pmc-release]
AID - jer-12-4-284 [pii]
AID - 10.12965/jer.1632698.349 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2016 Aug 31;12(4):284-92. doi: 10.12965/jer.1632698.349. 
      eCollection 2016 Aug.