PMID- 27656778
OWN - NLM
STAT- MEDLINE
DCOM- 20170616
LR  - 20180104
IS  - 1521-6950 (Electronic)
IS  - 1093-7404 (Linking)
VI  - 19
IP  - 8
DP  - 2016
TI  - Quantitative weight-of-evidence analysis of the persistence, bioaccumulation, 
      toxicity, and potential for long-range transport of the cyclic volatile methyl 
      siloxanes.
PG  - 345-379
AB  - Cyclic volatile methyl siloxanes (cVMSs) are highly volatile and have an unusual 
      combination of physicochemical properties, which are unlike those of 
      halocarbon-based chemicals used to establish criteria for identification of 
      persistent organic pollutants (POPs) that undergo long-range transport (LRT). A 
      transparent quantitative weight of evidence (QWoE) evaluation was conducted to 
      characterize their properties. Measurements of concentrations of cVMSs in the 
      environment are challenging, but currently, concentrations measured in robust 
      studies are all less than thresholds of toxicity. The cVMSs are moderately 
      persistent in air with half-lives </=11 d (greater than the criterion of 2 d) but 
      these compounds partition into the atmosphere, the final sink. The cVMSs are 
      rapidly degraded in dry soils, partition from wet soils into the atmosphere, and 
      are not classifiable as persistent in soils. Persistence in water and sediment is 
      variable, but the greatest concentrations in the environment are observed in 
      sediments. Based upon the measurements that have been made in the environment, 
      cVMSs should not be classified as persistent. Studies in food webs support a 
      conclusion that the cVMSs do not biomagnify, a conclusion that is consistent with 
      results of toxicokinetic studies. Concentrations in air in remote locations are 
      small and deposition has not been detected. Taken together, evidence indicates 
      that traditional measures of persistence and biomagnification used for legacy POP 
      are not suitable for cVMS. Refined approaches used here suggest that cVMSs are 
      not classifiable as persistent, bioaccumulative, or toxic. Further, these 
      chemicals do not undergo LRT in the sense of legacy POPs.
FAU - Bridges, Jim
AU  - Bridges J
AD  - a Department of Toxicology and Environmental Health , University of Surrey , 
      Guildford , Surrey , United Kingdom.
FAU - Solomon, Keith R
AU  - Solomon KR
AD  - b Centre for Toxicology, School of Environmental Sciences , University of Guelph 
      , Guelph , Ontario , Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160922
PL  - England
TA  - J Toxicol Environ Health B Crit Rev
JT  - Journal of toxicology and environmental health. Part B, Critical reviews
JID - 9802627
RN  - 0 (Environmental Pollutants)
RN  - 0 (Siloxanes)
SB  - IM
MH  - Animals
MH  - Environmental Exposure
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*analysis
MH  - *Food Chain
MH  - Humans
MH  - Plants
MH  - Siloxanes/*analysis
EDAT- 2016/09/23 06:00
MHDA- 2017/06/18 06:00
CRDT- 2016/09/23 06:00
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2017/06/18 06:00 [medline]
PHST- 2016/09/23 06:00 [entrez]
AID - 10.1080/10937404.2016.1200505 [doi]
PST - ppublish
SO  - J Toxicol Environ Health B Crit Rev. 2016;19(8):345-379. doi: 
      10.1080/10937404.2016.1200505. Epub 2016 Sep 22.