PMID- 27658188
OWN - NLM
STAT- MEDLINE
DCOM- 20170116
LR  - 20181202
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 111
IP  - 4
DP  - 2016 Nov
TI  - The International Haemovigilance Network Database for the Surveillance of Adverse 
      Reactions and Events in Donors and Recipients of Blood Components: technical 
      issues and results.
PG  - 409-417
LID - 10.1111/vox.12447 [doi]
AB  - BACKGROUND AND OBJECTIVES: The International Haemovigilance Network's ISTARE is 
      an online database for surveillance of all adverse reactions (ARs) and adverse 
      events (AEs) associated with donation of blood and transfusion of blood 
      components, irrespective of severity or the harm caused. ISTARE aims to unify the 
      collection and sharing of information with a view to harmonizing best practices 
      for haemovigilance systems around the world. MATERIALS AND METHODS: Adverse 
      reactionss and adverse events are recorded by blood component, type of reaction, 
      severity and imputability to transfusion, using internationally agreed standard 
      definitions. RESULTS: From 2006 to 2012, 125 national sets of annual aggregated 
      data were received from 25 countries, covering 132.8 million blood components 
      issued. The incidence of all ARs was 77.5 per 100 000 components issued, of which 
      25% were severe (19.1 per 100 000). Of 349 deaths (0.26 per 100 000), 58% were 
      due to the three ARs related to the respiratory system: transfusion-associated 
      circulatory overload (TACO, 27%), transfusion-associated acute lung injury 
      (TRALI, 19%) and transfusion-associated dyspnoea (TAD, 12%). Cumulatively, 594 
      477 donor complications were reported (rate 660 per 100 000), of which 2.9% were 
      severe. CONCLUSIONS: ISTARE is a well-established surveillance tool offering 
      important contributions to international efforts to maximize transfusion safety.
CI  - (c) 2016 International Society of Blood Transfusion.
FAU - Politis, C
AU  - Politis C
AD  - Coordinating Haemovigilance Centre (SKAE), Hellenic Centre for Disease Control 
      and Prevention, Athens, Greece.
FAU - Wiersum, J C
AU  - Wiersum JC
AD  - TRIP National Hemovigilance and Biovigilance Office, Leiden, The Netherlands.
FAU - Richardson, C
AU  - Richardson C
AD  - Panteion University of Social and Political Sciences, Athens, Greece.
FAU - Robillard, P
AU  - Robillard P
AD  - Hema-Quebec, Montreal, QC, Canada.
FAU - Jorgensen, J
AU  - Jorgensen J
AD  - Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Renaudier, P
AU  - Renaudier P
AD  - Agence Regionale de Sante, Nancy, France.
FAU - Faber, J-C
AU  - Faber JC
AD  - LuxConsulTrans(R), Banglamung, Thailand.
FAU - Wood, E M
AU  - Wood EM
AD  - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 
      Vic., Australia.
LA  - eng
PT  - Journal Article
DEP - 20160922
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
SB  - IM
MH  - Acute Lung Injury/epidemiology/etiology
MH  - Blood Donors
MH  - *Blood Safety
MH  - Blood Transfusion/statistics & numerical data
MH  - Epidemiological Monitoring
MH  - Humans
MH  - *Transfusion Reaction
OTO - NOTNLM
OT  - adverse events
OT  - adverse reactions
OT  - blood donation
OT  - blood transfusion
OT  - haemovigilance
OT  - transfusion errors
EDAT- 2016/09/23 06:00
MHDA- 2017/01/17 06:00
CRDT- 2016/09/23 06:00
PHST- 2016/05/11 00:00 [received]
PHST- 2016/08/03 00:00 [revised]
PHST- 2016/08/09 00:00 [accepted]
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2017/01/17 06:00 [medline]
PHST- 2016/09/23 06:00 [entrez]
AID - 10.1111/vox.12447 [doi]
PST - ppublish
SO  - Vox Sang. 2016 Nov;111(4):409-417. doi: 10.1111/vox.12447. Epub 2016 Sep 22.