PMID- 27658208 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 11 IP - 9 DP - 2016 TI - A Novel Inflammation- and Nutrition-Based Prognostic System for Patients with Laryngeal Squamous Cell Carcinoma: Combination of Red Blood Cell Distribution Width and Body Mass Index (COR-BMI). PG - e0163282 LID - 10.1371/journal.pone.0163282 [doi] LID - e0163282 AB - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is a head and neck cancer type. In this study, we introduced a novel inflammation- and nutrition-based prognostic system, referred to as COR-BMI (Combination of red blood cell distribution width and body mass index), for LSCC patients. METHODS: A total of 807 LSCC patients (784 male and 23 female, 22-87 y of age) who underwent surgery were enrolled in this retrospective cohort study. The patients were stratified by COR-BMI into three groups: COR-BMI (0) (RDW /= 25); COR-BMI (1) (RDW 13.1 and 18.5 /= 25); or COR-BMI (2) (RDW > 13.1 and BMI < 18.5). Cox regression models were used to investigate the association between COR-BMI and cancer-specific survival (CSS) rate among LSCC patients. RESULTS: The 5-y, 10-y, and 15-y CSS rates were 71.6%, 60.1%, and 55.4%, respectively. There were significant differences among the COR-BMI groups in age (< 60 versus >/= 60 y; P = 0.005) and T stage (T1, T2, T3, or T4; P = 0.013). Based on the results, COR-BMI (1 versus 0: HR = 1.76; 95% CI = 0.98-3.15; 2 versus 0: HR = 2.91; 95% CI = 1.53-5.54, P = 0.001) was a significant independent predictor of CSS. CONCLUSION: COR-BMI is a novel inflammation- and nutrition-based prognostic system, which could predict long-term survival in LSCC patients who underwent surgery. FAU - Fu, Yan AU - Fu Y AD - Department of Head and Neck Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. FAU - Mao, Yize AU - Mao Y AD - Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. FAU - Chen, Shiqi AU - Chen S AD - Department of Head and Neck Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. FAU - Yang, Ankui AU - Yang A AD - Department of Head and Neck Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. FAU - Zhang, Quan AU - Zhang Q AD - Department of Head and Neck Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. LA - eng PT - Journal Article DEP - 20160922 PL - United States TA - PLoS One JT - PloS one JID - 101285081 PMC - PMC5033418 COIS- The authors have declared that no competing interests exist. EDAT- 2016/09/23 06:00 MHDA- 2016/09/23 06:01 PMCR- 2016/09/22 CRDT- 2016/09/23 06:00 PHST- 2016/03/30 00:00 [received] PHST- 2016/09/05 00:00 [accepted] PHST- 2016/09/23 06:00 [entrez] PHST- 2016/09/23 06:00 [pubmed] PHST- 2016/09/23 06:01 [medline] PHST- 2016/09/22 00:00 [pmc-release] AID - PONE-D-16-12922 [pii] AID - 10.1371/journal.pone.0163282 [doi] PST - epublish SO - PLoS One. 2016 Sep 22;11(9):e0163282. doi: 10.1371/journal.pone.0163282. eCollection 2016.