PMID- 27658727
OWN - NLM
STAT- MEDLINE
DCOM- 20170703
LR  - 20220410
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 13
IP  - 4
DP  - 2017 Apr
TI  - Mechanisms of diabetes mellitus-induced bone fragility.
PG  - 208-219
LID - 10.1038/nrendo.2016.153 [doi]
AB  - The risk of fragility fractures is increased in patients with either type 1 
      diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is 
      decreased in T1DM, BMD in T2DM is often normal or even slightly elevated compared 
      with an age-matched control population. However, in both T1DM and T2DM, bone 
      turnover is decreased and the bone material properties and microstructure of bone 
      are altered; the latter particularly so when microvascular complications are 
      present. The pathophysiological mechanisms underlying bone fragility in diabetes 
      mellitus are complex, and include hyperglycaemia, oxidative stress and the 
      accumulation of advanced glycation endproducts that compromise collagen 
      properties, increase marrow adiposity, release inflammatory factors and 
      adipokines from visceral fat, and potentially alter the function of osteocytes. 
      Additional factors including treatment-induced hypoglycaemia, certain 
      antidiabetic medications with a direct effect on bone and mineral metabolism 
      (such as thiazolidinediones), as well as an increased propensity for falls, all 
      contribute to the increased fracture risk in patients with diabetes mellitus.
FAU - Napoli, Nicola
AU  - Napoli N
AD  - Unit of Endocrinology and Diabetes, Department of Medicine, Universita Campus 
      Bio-Medico di Roma, Via Alvaro di Portillo 21, 00128 Roma, Italy.
AD  - Division of Bone and Mineral Diseases, Washington University in St Louis, St 
      Louis, Missouri, USA.
AD  - Diabetes and Bone Network.
FAU - Chandran, Manju
AU  - Chandran M
AD  - Osteoporosis and Bone Metabolism Unit, Department of Endocrinology, Singapore 
      General Hospital, Outram Road, 169608 Singapore.
FAU - Pierroz, Dominique D
AU  - Pierroz DD
AD  - International Osteoporosis Foundation (IOF), Rue Juste-Olivier 9, 1260 Nyon, 
      Switzerland.
FAU - Abrahamsen, Bo
AU  - Abrahamsen B
AD  - University of Southern Denmark, Department of Medicine, Faculty of Health, 
      Holbaek Hospital, Holbaek, Denmark.
FAU - Schwartz, Ann V
AU  - Schwartz AV
AD  - Department of Epidemiology and Biostatistics, University of California, 550 16th 
      Street, San Francisco, California 94158, USA.
FAU - Ferrari, Serge L
AU  - Ferrari SL
AD  - Service of Bone Diseases, Geneva University Hospital and Faculty of Medicine, Rue 
      Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.
CN  - IOF Bone and Diabetes Working Group
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160923
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Accidental Falls/prevention & control
MH  - Animals
MH  - Bone Density/drug effects/physiology
MH  - Bone Remodeling/drug effects/*physiology
MH  - Diabetes Mellitus, Type 1/complications/drug therapy/*metabolism
MH  - Diabetes Mellitus, Type 2/complications/drug therapy/*metabolism
MH  - Fractures, Bone/etiology/*metabolism
MH  - Humans
MH  - Hyperglycemia/complications/drug therapy/metabolism
MH  - Hypoglycemic Agents/adverse effects/therapeutic use
EDAT- 2016/11/04 06:00
MHDA- 2017/07/04 06:00
CRDT- 2016/09/24 06:00
PHST- 2016/11/04 06:00 [pubmed]
PHST- 2017/07/04 06:00 [medline]
PHST- 2016/09/24 06:00 [entrez]
AID - nrendo.2016.153 [pii]
AID - 10.1038/nrendo.2016.153 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2017 Apr;13(4):208-219. doi: 10.1038/nrendo.2016.153. Epub 
      2016 Sep 23.