PMID- 27659299
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20231019
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 38
IP  - 2
DP  - 2017 Feb
TI  - Increased functional connectivity between the default mode and salience networks 
      in unmedicated adults with obsessive-compulsive disorder.
PG  - 678-687
LID - 10.1002/hbm.23408 [doi]
AB  - Deficits in attention have been implicated in Obsessive-Compulsive Disorder 
      (OCD), yet their neurobiological bases are poorly understood. In unmedicated 
      adults with OCD (n = 30) and healthy controls (n = 32), they used resting state 
      functional connectivity MRI (rs-fcMRI) to examine functional connectivity between 
      two neural networks associated with attentional processes: the default mode 
      network (DMN) and the salience network (SN). They then used path analyses to 
      examine putative relationships across three variables of interest: DMN-SN 
      connectivity, attention, and OCD symptoms. In the OCD compared with healthy 
      control participants, there was significantly reduced inverse connectivity 
      between the anterior medial prefrontal cortex (amPFC) and the anterior insular 
      cortex, regions within the DMN and SN, respectively. In OCD, reduced inverse 
      DMN-SN connectivity was associated with both increased OCD symptom severity and 
      decreased sustained attention. Path analyses were consistent with a potential 
      mechanistic explanation: OCD symptoms are associated with an imbalance in DMN-SN 
      networks that subserve attentional processes and this effect of OCD on DMN-SN 
      connectivity is associated with decreased sustained attention. This work builds 
      upon a growing literature suggesting that reduced inverse DMN-SN connectivity may 
      represent a trans-diagnostic marker of attentional processes and suggests a 
      potential mechanistic account of the relationship between OCD and attention. 
      Reduced inverse DMN-SN connectivity may be an important target for treatment 
      development to improve attention in individuals with OCD. Hum Brain Mapp 
      38:678-687, 2017. (c) 2016 Wiley Periodicals, Inc.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Posner, Jonathan
AU  - Posner J
AD  - Columbia College of Physicians and Surgeons, New York, New York.
AD  - New York State Psychiatric Institute, New York, New York.
FAU - Song, Inkyung
AU  - Song I
AD  - Columbia College of Physicians and Surgeons, New York, New York.
AD  - New York State Psychiatric Institute, New York, New York.
FAU - Lee, Seonjoo
AU  - Lee S
AD  - Columbia College of Physicians and Surgeons, New York, New York.
AD  - New York State Psychiatric Institute, New York, New York.
FAU - Rodriguez, Carolyn I
AU  - Rodriguez CI
AD  - Columbia College of Physicians and Surgeons, New York, New York.
AD  - New York State Psychiatric Institute, New York, New York.
FAU - Moore, Holly
AU  - Moore H
AD  - Columbia College of Physicians and Surgeons, New York, New York.
AD  - New York State Psychiatric Institute, New York, New York.
FAU - Marsh, Rachel
AU  - Marsh R
AD  - Columbia College of Physicians and Surgeons, New York, New York.
AD  - New York State Psychiatric Institute, New York, New York.
FAU - Blair Simpson, H
AU  - Blair Simpson H
AD  - Columbia College of Physicians and Surgeons, New York, New York.
AD  - New York State Psychiatric Institute, New York, New York.
LA  - eng
GR  - K24 MH091555/MH/NIMH NIH HHS/United States
GR  - T32 MH096679/MH/NIMH NIH HHS/United States
GR  - K23 MH091249/MH/NIMH NIH HHS/United States
GR  - K23 MH092434/MH/NIMH NIH HHS/United States
GR  - R21 MH093889/MH/NIMH NIH HHS/United States
GR  - R21 MH099388/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160923
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Mapping
MH  - Cerebral Cortex/diagnostic imaging/*physiopathology
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Status Schedule
MH  - Middle Aged
MH  - *Models, Neurological
MH  - Neural Pathways/*physiopathology
MH  - Obsessive-Compulsive Disorder/diagnostic imaging/*physiopathology
MH  - Young Adult
PMC - PMC5225141
MID - NIHMS817259
OTO - NOTNLM
OT  - attention
OT  - connectivity
OT  - default mode network
OT  - insula
OT  - obsessive-compulsive disorder
OT  - salience network
EDAT- 2016/09/24 06:00
MHDA- 2018/02/13 06:00
PMCR- 2016/09/23
CRDT- 2016/09/24 06:00
PHST- 2016/03/04 00:00 [received]
PHST- 2016/09/08 00:00 [revised]
PHST- 2016/09/12 00:00 [accepted]
PHST- 2016/09/24 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2016/09/24 06:00 [entrez]
PHST- 2016/09/23 00:00 [pmc-release]
AID - HBM23408 [pii]
AID - 10.1002/hbm.23408 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2017 Feb;38(2):678-687. doi: 10.1002/hbm.23408. Epub 2016 Sep 23.