PMID- 2766224
OWN - NLM
STAT- MEDLINE
DCOM- 19890927
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 64
IP  - 6
DP  - 1989 Sep 15
TI  - The prevalence of human T-cell leukemia virus type I infection in patients with 
      hematologic and nonhematologic diseases in an adult T-cell leukemia-endemic area 
      of Japan.
PG  - 1290-5
AB  - In order to clarify the prevalence of human T-cell leukemia virus type I (HTLV-I) 
      infection in the Kagoshima district, Japan, a highly endemic area for HTLV-I, 
      antibodies for HTLV-I (anti-HTLV-I) were examined in the sera of 6167 from 
      healthy residents and patients with various hematologic and nonhematologic 
      diseases. In healthy residents, including blood donors, the prevalence of 
      anti-HTLV-I was 11.9% (562/4741 persons). The prevalence increased with age, and 
      was significantly higher in in females than in males (P less than 0.01). The 
      prevalence of anti-HTLV-I in blood donors was 8.5%. In In hematologic diseases, 
      the prevalence of anti-HTLV-I was 98.3% in ATL, 28.9% in lymphoproliferative 
      disorders except ATL, and 10.6% in myeloproliferative disorders. In 
      nonhematologic diseases, the prevalence of anti-HTLV-I was shown to be 29.5% in 
      pulmonary tuberculosis, 25.8% in leprosy, 33.8% in chronic renal failure (CRF), 
      21.9% in autoimmune diseases, and 47.8% in strongyloidiasis. The various diseases 
      except myeloproliferative disorders had significantly higher prevalence of 
      anti-HTLV-I than healthy residents (P less than 0.01 or 0.05). For autoimmune 
      diseases, the prevalence of anti-HTLV-I in patients with blood transfusion 
      (55.6%) was higher than in those without blood transfusion (8.7%), and healthy 
      residents. In hemodialysis patients with CRF who had received blood transfusions 
      the prevalence of anti-HTLV-I increased with the number of blood transfusions. 
      Therefore, HTLV-I transmission via blood transfusion would partially explain 
      these high prevalence of anti-HTLV-I. However, the prevalence of anti-HTLV-I in 
      hemodialysis patients with CRF was statistically higher than that in healthy 
      residents, regardless of blood transfusion (P less than 0.01). Furthermore, 
      hemodialysis patients showed significantly higher prevalence of anti-HTLV-I than 
      healthy residents, even at a younger age. Patients with pulmonary tuberculosis 
      and leprosy showed the same results as hemodialysis patients. These results 
      suggest that possibility that HTLV-I infection has some relation not only to ATL 
      but also to other diseases. Therefore, it seems very important to halt the spread 
      of HTLV-I transmission as soon as possible.
FAU - Hanada, S
AU  - Hanada S
AD  - Second Department of Internal Medicine, Faculty of Medicine, Kagoshima 
      University, Japan.
FAU - Uematsu, T
AU  - Uematsu T
FAU - Iwahashi, M
AU  - Iwahashi M
FAU - Nomura, K
AU  - Nomura K
FAU - Utsunomiya, A
AU  - Utsunomiya A
FAU - Kodama, M
AU  - Kodama M
FAU - Ishibashi, K
AU  - Ishibashi K
FAU - Terada, A
AU  - Terada A
FAU - Saito, T
AU  - Saito T
FAU - Makino, T
AU  - Makino T
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Donors
MH  - Blood Transfusion
MH  - Female
MH  - HTLV-I Infections/complications/*epidemiology
MH  - Hematologic Diseases/complications
MH  - Humans
MH  - Japan
MH  - Leukemia-Lymphoma, Adult T-Cell/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Renal Dialysis
MH  - Serologic Tests
EDAT- 1989/09/15 00:00
MHDA- 1989/09/15 00:01
CRDT- 1989/09/15 00:00
PHST- 1989/09/15 00:00 [pubmed]
PHST- 1989/09/15 00:01 [medline]
PHST- 1989/09/15 00:00 [entrez]
AID - 10.1002/1097-0142(19890915)64:6<1290::aid-cncr2820640620>3.0.co;2-z [doi]
PST - ppublish
SO  - Cancer. 1989 Sep 15;64(6):1290-5. doi: 
      10.1002/1097-0142(19890915)64:6<1290::aid-cncr2820640620>3.0.co;2-z.