PMID- 27664822 OWN - NLM STAT- MEDLINE DCOM- 20170929 LR - 20220330 IS - 1464-3677 (Electronic) IS - 1353-4505 (Linking) VI - 28 IP - 6 DP - 2016 Dec 1 TI - The application of the Global Trigger Tool: a systematic review. PG - 640-649 LID - 10.1093/intqhc/mzw115 [doi] AB - PURPOSE: This study describes the use of, and modifications and additions made to, the Global Trigger Tool (GTT) since its first release in 2003, and summarizes its findings with respect to counting and characterizing adverse events (AEs). DATA SOURCES: Peer-reviewed literature up to 31st December 2014. STUDY SELECTION: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. DATA EXTRACTION: Two authors extracted and compiled the demographics, methodologies and results of the selected studies. RESULTS OF DATA SYNTHESIS: Of the 48 studies meeting the eligibility criteria, 44 collected data from inpatient medical records and four from general practice records. Studies were undertaken in 16 countries. Over half did not follow the standard GTT protocol regarding the number of reviewers used. 'Acts of omission' were included in one quarter of studies. Incident reporting detected between 2% and 8% of AEs that were detected with the GTT. Rates of AEs varied in general inpatient studies between 7% and 40%. Infections, problems with surgical procedures and medication were the most common incident types. CONCLUSION: The GTT is a flexible tool used in a range of settings with varied applications. Substantial differences in AE rates were evident across studies, most likely associated with methodological differences and disparate reviewer interpretations. AE rates should not be compared between institutions or studies. Recommendations include adding 'omission' AEs, using preventability scores for priority setting, and re-framing the GTT's purpose to understand and characterize AEs rather than just counting them. CI - (c) The Author 2016. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com FAU - Hibbert, Peter D AU - Hibbert PD AD - Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Macquarie University, New South Wales 2109, Australia. AD - Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia. FAU - Molloy, Charlotte J AU - Molloy CJ AD - Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Macquarie University, New South Wales 2109, Australia. AD - Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia. FAU - Hooper, Tamara D AU - Hooper TD AD - Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Macquarie University, New South Wales 2109, Australia. AD - Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia. FAU - Wiles, Louise K AU - Wiles LK AD - Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Macquarie University, New South Wales 2109, Australia. AD - Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia. FAU - Runciman, William B AU - Runciman WB AD - Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Macquarie University, New South Wales 2109, Australia. AD - Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia. AD - Australian Patient Safety Foundation, PO Box 2471, IPC CWE-53, Adelaide, South Australia 5001, Australia. FAU - Lachman, Peter AU - Lachman P AD - Great Ormond Street Hospital NHS Foundation Trust, Great Ormond St, London WC1N 3JH, UK. FAU - Muething, Stephen E AU - Muething SE AD - James M. Anderson Center for HealthCare Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. FAU - Braithwaite, Jeffrey AU - Braithwaite J AD - Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Macquarie University, New South Wales 2109, Australia. LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - England TA - Int J Qual Health Care JT - International journal for quality in health care : journal of the International Society for Quality in Health Care JID - 9434628 SB - IM MH - Adverse Drug Reaction Reporting Systems/*organization & administration MH - Drug-Related Side Effects and Adverse Reactions/prevention & control MH - General Practice/standards MH - Humans MH - Inpatients MH - Medical Errors/*prevention & control MH - Patient Safety/*standards OTO - NOTNLM OT - Global Trigger Tool OT - adverse events OT - patient safety OT - quality of care OT - systematic review EDAT- 2016/09/25 06:00 MHDA- 2017/09/30 06:00 CRDT- 2016/09/25 06:00 PHST- 2016/09/06 00:00 [received] PHST- 2016/08/30 00:00 [accepted] PHST- 2016/09/25 06:00 [pubmed] PHST- 2017/09/30 06:00 [medline] PHST- 2016/09/25 06:00 [entrez] AID - mzw115 [pii] AID - 10.1093/intqhc/mzw115 [doi] PST - ppublish SO - Int J Qual Health Care. 2016 Dec 1;28(6):640-649. doi: 10.1093/intqhc/mzw115.