PMID- 27665232 OWN - NLM STAT- MEDLINE DCOM- 20180517 LR - 20220410 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 36 IP - 5 DP - 2017 Oct TI - Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH) style diet, and metabolic health in U.S. adults. PG - 1301-1309 LID - S0261-5614(16)30217-5 [pii] LID - 10.1016/j.clnu.2016.08.018 [doi] AB - BACKGROUND & AIMS: There is sparse evidence on the relationship between the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH) style diet, and metabolic health, especially comparing cardiometabolic phenotypes among in normal weight and obese populations. We aimed to investigate the association of the Mediterranean diet scores (MDS) and DASH index with metabolically healthy obese (MHO) and metabolically obese normal weight (MONW) phenotypes in a representative U.S. METHODS: MDS and DASH index were calculated using dietary data from 2767 adults aged 20-90 years without any prior diagnosis of cancer or cardiovascular disease from the National Health and Nutrition Examination Survey III, 1988-1994. MHO and MONW individuals were identified using fasting glucose, insulin resistance, blood pressure, triglycerides, C-reactive protein, and high-density lipoprotein-cholesterol. RESULTS: Higher MDS was associated with higher odds of MHO phenotype (odds ratio (OR)(T3 vs T1), 2.57 [95% confidence interval (CI), 1.04-6.35]; P trend = 0.04), and higher DASH index was associated with lower odds of MONW phenotype (OR(T3 vs T1,) 0.59 [95% CI, 0.38-0.93]; P trend = 0.03) only in the younger age group (<45 years for men or premenopausal women). No significant associations of MDS and DASH index with MHO and MONW phenotypes were observed in the older age group (>/=45 years for men or postmenopausal women). CONCLUSIONS: Adherence to Mediterranean diet or DASH style diet was favorably associated with MHO and MONW phenotypes only in the younger age group, suggesting that potential dietary intervention to prevent cardiometabolic disease differ by age group. CI - Published by Elsevier Ltd. FAU - Park, Yong-Moon Mark AU - Park YM AD - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. FAU - Steck, Susan E AU - Steck SE AD - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Fung, Teresa T AU - Fung TT AD - Department of Nutrition, Simmons College, Boston, MA, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. FAU - Zhang, Jiajia AU - Zhang J AD - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Hazlett, Linda J AU - Hazlett LJ AD - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Han, Kyungdo AU - Han K AD - Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Lee, Seung-Hwan AU - Lee SH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Kwon, Hyuk-Sang AU - Kwon HS AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Merchant, Anwar T AU - Merchant AT AD - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. Electronic address: merchant@mailbox.sc.edu. LA - eng PT - Journal Article DEP - 20160908 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Blood Glucose) RN - 0 (Triglycerides) RN - 9007-41-4 (C-Reactive Protein) RN - 97C5T2UQ7J (Cholesterol) SB - IM CIN - Clin Nutr. 2018 Feb;37(1):410. PMID: 29249530 CIN - Clin Nutr. 2018 Apr;37(2):755. PMID: 29409660 MH - Adult MH - *Age Factors MH - Aged MH - Aged, 80 and over MH - Anthropometry MH - Blood Glucose/metabolism MH - Blood Pressure MH - C-Reactive Protein MH - Cholesterol/blood MH - Cross-Sectional Studies MH - *Diet, Mediterranean MH - *Dietary Approaches To Stop Hypertension MH - Exercise MH - Female MH - Humans MH - Hypertension/blood/*prevention & control MH - Insulin Resistance MH - Male MH - Middle Aged MH - Neoplasms/blood/*prevention & control MH - Nutrition Assessment MH - Nutrition Surveys MH - Obesity MH - Socioeconomic Factors MH - Triglycerides/blood MH - United States MH - Young Adult OTO - NOTNLM OT - Dietary Approaches to Stop Hypertension style diet OT - Mediterranean diet OT - Metabolically healthy obese OT - Metabolically obese normal weight OT - National Health and Nutrition Examination Survey III EDAT- 2016/09/26 06:00 MHDA- 2018/05/18 06:00 CRDT- 2016/09/26 06:00 PHST- 2016/03/21 00:00 [received] PHST- 2016/06/09 00:00 [revised] PHST- 2016/08/24 00:00 [accepted] PHST- 2016/09/26 06:00 [pubmed] PHST- 2018/05/18 06:00 [medline] PHST- 2016/09/26 06:00 [entrez] AID - S0261-5614(16)30217-5 [pii] AID - 10.1016/j.clnu.2016.08.018 [doi] PST - ppublish SO - Clin Nutr. 2017 Oct;36(5):1301-1309. doi: 10.1016/j.clnu.2016.08.018. Epub 2016 Sep 8.