PMID- 27665506
OWN - NLM
STAT- MEDLINE
DCOM- 20170407
LR  - 20170407
IS  - 1423-0143 (Electronic)
IS  - 1420-4096 (Linking)
VI  - 41
IP  - 5
DP  - 2016
TI  - Cardio-Renal Syndrome Type 4: The Correlation Between Cardiorenal Ultrasound 
      Parameters.
PG  - 654-662
AB  - Bakground/Aims: Cardiovascular diseases represent the leading causes of morbidity 
      and mortality in patients with cronich kidney disease (CKD). The pathogenesis 
      includes a complex, bidirectional interaction between heart and kidney termed 
      cardiorenal syndrome type 4. The aim of study was to evaluate the association 
      between renal and cardiovascular ultrasonographic parameters and identify early 
      markers of cardiovascular risk. METHODS: A total of 35 patients with CKD and 25 
      healthy controls, were enrolled and we have evaluated inflammatory indexes, 
      mineral metabolism, renal function, renal and cardiovascular ultrasonographic 
      parameters. RESULTS: Tricuspid anular plane systolic excursion (TAPSE) and 
      estimated pulmonary artery systolic pressure (ePAPs) showed a statistically 
      significant difference between CKD patients and healthy controls (p<0.001, 
      p=0.05). Also 25 hydroxyvitaminD (25-OH-VitD), parathyroid hormone (iPTH), 
      posphorus, serum uric acid, renal resistive index (RRI) and C-reactive protein 
      (CRP) showed a significant difference between the two groups (p=0.002, p<0.001, 
      p<0.001, p<0.001, p<0.001, p<0.001). Moreover the TAPSE correlated positively 
      with estimated glomerula filtration rate (eGFR) and negatively with RRI (p=0.05, 
      p=0.008), while ePAPs correlated negatively with eGFR and positively with RRI 
      (p=0.029, p<0.001). CONCLUSION: CKD can contribute to the development and 
      progression of right ventricle dysfunction with endothelial dysfunction, 
      inflammation and mineral metabolism disorders. Accurate assessment of right 
      ventricular function is recommended in patients with CKD. RRI and 
      echocardiographic parameters can be an important instrument for the diagnosis, 
      prognosis and therapeutic assessment of cardio-renal syndrome in these patients.
CI  - (c) 2016 The Author(s) Published by S. Karger AG, Basel.
FAU - Lai, Silvia
AU  - Lai S
AD  - Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
FAU - Ciccariello, Mauro
AU  - Ciccariello M
FAU - Dimko, Mira
AU  - Dimko M
FAU - Galani, Alessandro
AU  - Galani A
FAU - Lucci, Silvio
AU  - Lucci S
FAU - Cianci, Rosario
AU  - Cianci R
FAU - Mariotti, Amalia
AU  - Mariotti A
LA  - eng
PT  - Journal Article
DEP - 20160926
PL  - Switzerland
TA  - Kidney Blood Press Res
JT  - Kidney & blood pressure research
JID - 9610505
RN  - 0 (Minerals)
SB  - IM
MH  - Aged
MH  - Cardio-Renal Syndrome/diagnosis/*diagnostic imaging
MH  - Cardiovascular Diseases
MH  - Case-Control Studies
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Male
MH  - Middle Aged
MH  - Minerals/metabolism
MH  - Renal Insufficiency, Chronic/*complications
MH  - Ultrasonography
MH  - Ventricular Dysfunction, Right/diagnosis/etiology
EDAT- 2016/10/21 06:00
MHDA- 2017/04/08 06:00
CRDT- 2016/09/26 06:00
PHST- 2016/08/03 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/04/08 06:00 [medline]
PHST- 2016/09/26 06:00 [entrez]
AID - 000447934 [pii]
AID - 10.1159/000447934 [doi]
PST - ppublish
SO  - Kidney Blood Press Res. 2016;41(5):654-662. doi: 10.1159/000447934. Epub 2016 Sep 
      26.