PMID- 27667549
OWN - NLM
STAT- MEDLINE
DCOM- 20170921
LR  - 20221207
IS  - 0975-0711 (Electronic)
IS  - 0254-8860 (Linking)
VI  - 35
IP  - 5
DP  - 2016 Sep
TI  - Prevalence and predictors of delayed gastric emptying among Indian patients with 
      long-standing type 2 diabetes mellitus.
PG  - 385-392
AB  - BACKGROUND AND AIMS: Upper gastrointestinal symptoms are more prevalent among 
      type 2 diabetes mellitus (T2DM) patients. The prevalence of delayed gastric 
      emptying (GE) and factors predictive of it have not been studied in Indian T2DM 
      patients and the present study aimed to study the same. METHODS: This 
      hospital-based cross-sectional study involved adult (age between 18 and 65 years) 
      outpatients with T2DM of >/=5-year duration. Measurements of GE of a labelled 
      standardized solid rice idli meal by gastric emptying scintigraphy (GES), 
      symptoms of delayed GE (by standardized questionnaire) and autonomic function by 
      cardiovascular autonomic function tests (AFTs) were carried out. Thirty healthy 
      subjects served as controls for GES and AFTs. RESULTS: One hundred and forty T2DM 
      patients (age range: 32-65 years) were studied. Delayed GE was documented in 
       approximately 29 % (40/140) and rapid GE in 2 % (3/140) of T2DM patients. Univariate analysis 
      showed significant positive association between delayed GE and duration of DM, 
      body mass index (BMI), HbA1c, retinopathy, peripheral neuropathy, autonomic 
      dysfunction and coronary artery disease (p < 0.05 for all). However, there was no 
      significant correlation of age, sex, symptoms suggestive of gastroparesis and 
      nephropathy with delayed GE. Hypoglycemic episodes were significantly more 
      frequent in those with delayed GE (p < 0.05). Multiple logistic regression 
      analysis revealed only BMI and HbA1c to be significant independent predictors of 
      delayed GE. CONCLUSION: Presence and severity of symptoms of gastroparesis did 
      not predict delayed GE. Delayed GE, irrespective of symptoms, was associated with 
      microvascular and macrovascular diabetic complications and increased risk of 
      hypoglycemic episodes. HbA(1c) and BMI were independent predictors of delayed GE.
FAU - Anudeep, Venkata
AU  - Anudeep V
AD  - Department of General Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, Pondicherry, 605 006, India.
FAU - Vinod, Kolar Vishwanath
AU  - Vinod KV
AD  - Department of General Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, Pondicherry, 605 006, India. 
      drkvv@rediffmail.com.
FAU - Pandit, Nandini
AU  - Pandit N
AD  - Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, Pondicherry, 605 006, India.
FAU - Sharma, Vivek Kumar
AU  - Sharma VK
AD  - Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Puducherry, Pondicherry, 605 006, India.
FAU - Dhanapathi, Halanaik
AU  - Dhanapathi H
AD  - Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, Pondicherry, 605 006, India.
FAU - Dutta, Tarun Kumar
AU  - Dutta TK
AD  - Department of General Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, Pondicherry, 605 006, India.
FAU - Sujiv, Akkilagunta
AU  - Sujiv A
AD  - Department of Preventive and Social Medicine, Jawaharlal Institute of 
      Postgraduate Medical Education and Research, Puducherry, Pondicherry, 605 006, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20160926
PL  - India
TA  - Indian J Gastroenterol
JT  - Indian journal of gastroenterology : official journal of the Indian Society of 
      Gastroenterology
JID - 8409436
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications/*physiopathology
MH  - Female
MH  - Forecasting
MH  - *Gastric Emptying
MH  - Gastrointestinal Diseases/*epidemiology/*etiology/*physiopathology
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hypoglycemia
MH  - India/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Young Adult
OTO - NOTNLM
OT  - Autonomic dysfunction
OT  - Gastric emptying
OT  - Gastroparesis
OT  - Idli meal
OT  - Scintigraphy
OT  - Type 2 diabetes
EDAT- 2016/10/19 06:00
MHDA- 2017/09/22 06:00
CRDT- 2016/09/27 06:00
PHST- 2016/05/29 00:00 [received]
PHST- 2016/09/01 00:00 [accepted]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2017/09/22 06:00 [medline]
PHST- 2016/09/27 06:00 [entrez]
AID - 10.1007/s12664-016-0694-4 [pii]
AID - 10.1007/s12664-016-0694-4 [doi]
PST - ppublish
SO  - Indian J Gastroenterol. 2016 Sep;35(5):385-392. doi: 10.1007/s12664-016-0694-4. 
      Epub 2016 Sep 26.