PMID- 27668708
OWN - NLM
STAT- MEDLINE
DCOM- 20171026
LR  - 20171201
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 224
DP  - 2016 Dec 1
TI  - Usefulness of late gadolinium enhancement MRI combined with stress imaging in 
      predictive significant coronary stenosis in new-diagnosed left ventricular 
      dysfunction.
PG  - 337-342
LID - S0167-5273(16)32295-1 [pii]
LID - 10.1016/j.ijcard.2016.09.039 [doi]
AB  - BACKGROUND: To evaluate the accuracy of late gadolinium enhancement (LGE) cardiac 
      magnetic resonance (CMR) and imaging stress test in predicting significant 
      coronary artery disease (CAD) in left ventricular (LV) dysfunction. METHODS: We 
      enrolled 187 consecutive out-patients (61+/-17years) with new evidence of depressed 
      (<45%) ejection fraction and no history of previous heart diseases and absence of 
      Q-waves. All patients underwent coronary angiography (CA) and to LGE-CMR 
      examination to identify ischemic and non-ischemic LGE. All patients underwent 
      stress imaging to determine the presence of myocardial ischemia. RESULTS: 
      Ischemic-LGE was found in 83 patients and non-ischemic-LGE in 104. Significant 
      CAD on CA was found in 86/187 patients. Ischemic-LGE showed a specificity of 94%, 
      a sensitivity of 89% and an accuracy of 92% in identifying significant CAD. 
      Imaging stress test was negative in 98/105 patients without CAD, and positive in 
      42/82 with significant CAD, showing a specificity of 93%, a sensitivity of 51% 
      and an accuracy of 75% in identifying CAD. Combining CMR and stress test imaging, 
      94 patients had ischemic-LGE pattern and/or positive stress test for ischemia; of 
      these 81/94 had significant CAD on CA and 13 had no CAD. Among the 93 patients 
      with both tests negative, significant CAD was found in 5/93 patients. The 
      combination of LGE and stress respect to only LGE did not improve the diagnostic 
      accuracy (90 vs 92% respectively). CONCLUSION: LGE-CMR had high accuracy in 
      predicting significant CAD in ischemic LV dysfunction or as a bystander in non 
      ischemic dysfunction.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Di Bella, Gianluca
AU  - Di Bella G
AD  - CNR, Institute of Clinical Physiology, Pisa, Italy; Department of Clinical and 
      Experimental Medicine, University of Messina, Messina, Italy. Electronic address: 
      gianluca.dibella@tiscali.it.
FAU - Pingitore, Alessandro
AU  - Pingitore A
AD  - CNR, Institute of Clinical Physiology, Pisa, Italy.
FAU - Piaggi, Paolo
AU  - Piaggi P
AD  - Section of Endocrinology, Department of Clinical and Experimental Medicine, 
      University of Pisa, Pisa, Italy.
FAU - Pizzino, Fausto
AU  - Pizzino F
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina, 
      Italy.
FAU - Barison, Andrea
AU  - Barison A
AD  - Fondazione Toscana G. Monasterio, CNR - Regione Toscana, Pisa, Italy.
FAU - Terrizzi, Anna
AU  - Terrizzi A
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina, 
      Italy.
FAU - d'angelo, Miriam
AU  - d'angelo M
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina, 
      Italy.
FAU - Todiere, Giancarlo
AU  - Todiere G
AD  - Fondazione Toscana G. Monasterio, CNR - Regione Toscana, Pisa, Italy.
FAU - Quattrocchi, Salvina
AU  - Quattrocchi S
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina, 
      Italy.
FAU - Carerj, Scipione
AU  - Carerj S
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina, 
      Italy.
FAU - Emdin, Michele
AU  - Emdin M
AD  - Fondazione Toscana G. Monasterio, CNR - Regione Toscana, Pisa, Italy.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Fondazione Toscana G. Monasterio, CNR - Regione Toscana, Pisa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160919
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Int J Cardiol. 2017 Feb 15;229:62. PMID: 27884565
MH  - Aged
MH  - Coronary Angiography/methods
MH  - *Coronary Stenosis/complications/diagnosis
MH  - Coronary Vessels/*diagnostic imaging
MH  - Dimensional Measurement Accuracy
MH  - Exercise Test/methods
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging, Cine/methods
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Ischemia/complications/diagnosis
MH  - Myocardial Perfusion Imaging/methods
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - *Ventricular Dysfunction, Left/diagnosis/etiology
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Heart failure
OT  - Late gadolinium enhancement
OT  - Left ventricular dysfunction
OT  - Significant coronary artery disease
EDAT- 2016/10/25 06:00
MHDA- 2017/10/27 06:00
CRDT- 2016/09/27 06:00
PHST- 2016/06/20 00:00 [received]
PHST- 2016/08/29 00:00 [revised]
PHST- 2016/09/15 00:00 [accepted]
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2016/09/27 06:00 [entrez]
AID - S0167-5273(16)32295-1 [pii]
AID - 10.1016/j.ijcard.2016.09.039 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Dec 1;224:337-342. doi: 10.1016/j.ijcard.2016.09.039. Epub 
      2016 Sep 19.