PMID- 27669020
OWN - NLM
STAT- MEDLINE
DCOM- 20170123
LR  - 20181202
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 41
IP  - 10
DP  - 2016 Oct
TI  - Wild blueberry consumption attenuates local inflammation in the perivascular 
      adipose tissue of obese Zucker rats.
PG  - 1045-1051
AB  - Perivascular adipose tissue (PVAT) has been shown to play important roles in 
      regulating vascular tone and linking local and systemic vascular inflammation. We 
      examined the impact of PVAT on phenylephrine-mediated vasoconstriction in the 
      aorta of obese Zucker rats (OZR) and their lean littermates (LZR) by comparing 
      aortic rings with or without PVAT. Subsequently we placed OZR and LZR on a 
      control (C) or an 8% wild blueberry (WB) diet and evaluated the effect of WB 
      consumption on such response. PVAT-released adipokine concentrations were also 
      measured as a function of WB diet. Maximal constrictor force (Fmax) in aortic 
      rings without PVAT was significantly lower in OZR-C compared with LZR-C (0.41 +/- 
      0.05 and 0.71 +/- 0.06 g, respectively). Following WB diet, Fmax significantly 
      increased in OZR (0.54 +/- 0.06 g). In aortas with intact PVAT, Fmax was 
      significantly lower in all groups (0.31 +/- 0.06 OZR-C, 0.30 +/- 0.05 OZR-WB, 0.29 +/- 
      0.03 LZR-C, and 0.30 +/- 0.04 g LZR-WB), but no difference was observed between 
      treatments. PVAT concentrations of monocyte chemoactractant protein 1 (MCP-1), 
      tumor necrosis factor alpha, and adiponectin were significantly higher in OZR 
      compared with LZR (+102%, +108%, and +45%, respectively). Following WB diet, PVAT 
      concentrations of interleukin-8 were significantly lower in both OZR (-37%) and 
      LZR (-30%), while adiponectin concentrations significantly increased in both OZR 
      (+11%) and LZR (+16%). MCP-1 concentrations significantly decreased (-31%) in the 
      PVAT of OZR with the WB diet. WB consumption appears to attenuate local 
      inflammation in PVAT, which may impact systemic vascular inflammation and 
      endothelial function.
FAU - Vendrame, Stefano
AU  - Vendrame S
AD  - a School of Food and Agriculture, Department of Food Science and Human Nutrition, 
      University of Maine, 232 Hitchner Hall, Orono, ME 04469, USA.
FAU - Tsakiroglou, Panagiotis
AU  - Tsakiroglou P
AD  - a School of Food and Agriculture, Department of Food Science and Human Nutrition, 
      University of Maine, 232 Hitchner Hall, Orono, ME 04469, USA.
FAU - Kristo, Aleksandra S
AU  - Kristo AS
AD  - b Department of Nutrition and Dietetics, Istanbul Yeni Yuzyil University, 26 
      Yilanli Ayazma Cad., 34010 Cevizlibag Istanbul, Turkey.
FAU - Schuschke, Dale A
AU  - Schuschke DA
AD  - c Applied Physiology and Biophysics, University of Louisville School of Medicine, 
      Louisville, KY 40292, USA.
FAU - Klimis-Zacas, Dorothy
AU  - Klimis-Zacas D
AD  - a School of Food and Agriculture, Department of Food Science and Human Nutrition, 
      University of Maine, 232 Hitchner Hall, Orono, ME 04469, USA.
LA  - eng
PT  - Journal Article
DEP - 20160926
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Adiponectin)
RN  - 0 (Adipoq protein, rat)
RN  - 0 (Biomarkers)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vasoconstrictor Agents)
RN  - 1WS297W6MV (Phenylephrine)
SB  - IM
MH  - Adiponectin/blood/metabolism
MH  - Adipose Tissue, White/drug effects/immunology/metabolism/*physiopathology
MH  - Animals
MH  - Aorta, Thoracic
MH  - Arteries/drug effects/immunology/metabolism/*physiopathology
MH  - Biomarkers/blood/metabolism
MH  - *Blueberry Plants
MH  - Chemokine CCL2/blood/metabolism
MH  - Endothelium, Vascular/drug effects/immunology/metabolism/*physiopathology
MH  - Food, Preserved
MH  - *Fruit
MH  - Interleukin-8/blood
MH  - Obesity/*diet therapy/immunology/pathology/physiopathology
MH  - Phenylephrine/pharmacology
MH  - Random Allocation
MH  - Rats, Zucker
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Vasculitis/etiology/*prevention & control
MH  - Vasoconstriction/drug effects
MH  - Vasoconstrictor Agents/pharmacology
OTO - NOTNLM
OT  - MCP-1
OT  - PVAT
OT  - TNF-alpha
OT  - Zucker rat
OT  - anthocyanines
OT  - anthocyanins
OT  - bleuets
OT  - blueberries
OT  - cyclooxygenase
OT  - cyclooxygenase
OT  - endothelial function
OT  - fonction endotheliale oxyde nitrique synthase
OT  - inflammation
OT  - metabolic syndrome
OT  - nitric oxide synthase
OT  - rat Zucket
OT  - syndrome metabolique
EDAT- 2016/09/27 06:00
MHDA- 2017/01/24 06:00
CRDT- 2016/09/27 06:00
PHST- 2016/09/27 06:00 [pubmed]
PHST- 2017/01/24 06:00 [medline]
PHST- 2016/09/27 06:00 [entrez]
AID - 10.1139/apnm-2016-0160 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2016 Oct;41(10):1045-1051. doi: 10.1139/apnm-2016-0160. 
      Epub 2016 Sep 26.