PMID- 27670353
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20231213
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 25
IP  - 2
DP  - 2017 Apr
TI  - Combined DOG1 and Mammaglobin Immunohistochemistry Is Comparable to 
      ETV6-breakapart Analysis for Differentiating Between Papillary Cystic Variants of 
      Acinic Cell Carcinoma and Mammary Analogue Secretory Carcinoma.
PG  - 127-140
LID - 10.1177/1066896916670005 [doi]
AB  - BACKGROUND: We investigated the reliability of combined DOG1 and mammaglobin 
      immunohistochemistry compared with ETV6 fluorescence in situ hybridization (FISH) 
      in the assessment of salivary tumors previously diagnosed as acinic cell 
      carcinoma (ACC). Ultrastructural features of cases reclassified as mammary 
      analogue secretory carcinoma (MASC) were assessed by transmission electron 
      microscopy (TEM). METHODS: Immunohistochemical (IHC) reactivity to DOG1 and 
      mammaglobin was validated against FISH targeting the ETV6 gene in all 14 cases. 
      RESULTS: Three cases with papillary cystic histomorphology previously diagnosed 
      as ACC were revised to MASC. TEM features of the ETV6 rearrangement-positive MASC 
      cases showed large numbers of secretory granules with extrusion into the 
      intercellular spaces, well-developed endoplasmic reticulum, lipid-laden vacuoles, 
      well-formed microvilli, and large lining cystic spaces. CONCLUSIONS: Combined 
      DOG1 and mammaglobin immunohistochemistry is comparable to ETV6 -breakapart 
      analysis for differentiating between papillary cystic variants of ACC and MASC.
FAU - Said-Al-Naief, Nasser
AU  - Said-Al-Naief N
AD  - 1 Oregon Health Sciences University, Portland, OR, USA.
FAU - Carlos, Roman
AU  - Carlos R
AD  - 2 Centro Clinico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, 
      Guatemala.
FAU - Vance, Gail H
AU  - Vance GH
AD  - 3 Department of Medical and Molecular Genetics Indiana University School of 
      Medicine Indianapolis, IN, USA.
FAU - Miller, Caroline
AU  - Miller C
AD  - 4 Department of Anatomy and Cell Biology Indiana University School of Medicine 
      Indianapolis, IN, USA.
FAU - Edwards, Paul C
AU  - Edwards PC
AD  - 5 Department of Oral Pathology, Medicine and Radiology Indiana University School 
      of DentistryIndianapolis, IN, USA.
LA  - eng
PT  - Journal Article
DEP - 20160926
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (ANO1 protein, human)
RN  - 0 (Anoctamin-1)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Chloride Channels)
RN  - 0 (ETV6-NTRK3 fusion protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anoctamin-1
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Acinar Cell/*diagnosis/ultrastructure
MH  - Chloride Channels/analysis/biosynthesis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mammary Analogue Secretory Carcinoma/*diagnosis
MH  - Microscopy, Electron, Transmission
MH  - Middle Aged
MH  - Neoplasm Proteins/analysis/biosynthesis
MH  - Oncogene Proteins, Fusion/genetics
MH  - Proto-Oncogene Proteins c-ets/analysis/biosynthesis
MH  - Repressor Proteins/analysis/biosynthesis
MH  - Salivary Gland Neoplasms/*diagnosis/ultrastructure
MH  - Young Adult
MH  - ETS Translocation Variant 6 Protein
OTO - NOTNLM
OT  - DOG1
OT  - ETV6
OT  - FISH
OT  - acinic cell carcinoma
OT  - immunohistochemistry
OT  - mammaglobin
OT  - mammary analogue secretory carcinoma
EDAT- 2016/09/28 06:00
MHDA- 2017/07/20 06:00
CRDT- 2016/09/28 06:00
PHST- 2016/09/28 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
PHST- 2016/09/28 06:00 [entrez]
AID - 1066896916670005 [pii]
AID - 10.1177/1066896916670005 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2017 Apr;25(2):127-140. doi: 10.1177/1066896916670005. Epub 
      2016 Sep 26.