PMID- 27670428
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20220321
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 17
IP  - 1
DP  - 2016 Dec
TI  - Altered functional connectivity of the marginal division in migraine: a 
      resting-state fMRI study.
PG  - 89
LID - 89
AB  - BACKGROUND: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone 
      between the neostriatum and the globus pallidus, and previous documents 
      demonstrated that it was involved in the modulation of pain. The aim of this 
      study is to investigate the roles of the MrD of the human brain in the 
      chronicization migraine using resting state functional magnetic resonance imaging 
      (rs-fMRI). METHODS: Conventional MRI, 3D structure images, and rs-fMRI were 
      performed in 18 patients with episodic migraines (EM), 16 patients with chronic 
      migraine (CM), 44 patients with medication overuse headache plus chronic migraine 
      (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation 
      on structural images, and was selected as the seed to calculate the functional 
      connectivity (FC). RESULTS: Compared with the NC group, the decreased FC of MrD 
      was observed in the EM and CM groups, and increased FC of MrD was demonstrated in 
      all patient groups. Compared with the EM group, the decreased FC of MrD was 
      revealed in the CM and MOH + CM groups, and the increased FC occurred only in the 
      CM group. Increased FC of MrD alone was observed in the MOH + CM group compared 
      with that in the CM group. CONCLUSION: This study confirmed the double 
      neuromodulation network of MrD in pain modulation and migraine chronicization; 
      however, the mechanism requires further investigation.
FAU - Chen, Zhiye
AU  - Chen Z
AD  - Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
AD  - Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Chen, Xiaoyan
AU  - Chen X
AD  - Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Liu, Mengqi
AU  - Liu M
AD  - Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Liu, Shuangfeng
AU  - Liu S
AD  - Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Shu, Siyun
AU  - Shu S
AD  - Institute of Cognitive Neuroscience, South China Normal University, Guangzhou, 
      510631, China.
FAU - Ma, Lin
AU  - Ma L
AD  - Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Yu, Shengyuan
AU  - Yu S
AD  - Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China. 
      yusy1963@126.com.
LA  - eng
PT  - Journal Article
DEP - 20160926
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
SB  - IM
MH  - Adult
MH  - Brain Mapping/*methods
MH  - Chronic Pain/*physiopathology
MH  - Female
MH  - Headache Disorders, Secondary/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*physiopathology
MH  - Neostriatum/*physiopathology
MH  - Nerve Net/*physiopathology
PMC - PMC5037100
OTO - NOTNLM
OT  - Functional connectivity
OT  - Marginal division of the neostriatum
OT  - Migraine
OT  - fMRI
EDAT- 2016/09/28 06:00
MHDA- 2017/01/04 06:00
PMCR- 2016/09/26
CRDT- 2016/09/28 06:00
PHST- 2016/07/25 00:00 [received]
PHST- 2016/09/22 00:00 [accepted]
PHST- 2016/09/28 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
PHST- 2016/09/28 06:00 [entrez]
PHST- 2016/09/26 00:00 [pmc-release]
AID - 10.1186/s10194-016-0682-1 [pii]
AID - 682 [pii]
AID - 10.1186/s10194-016-0682-1 [doi]
PST - ppublish
SO  - J Headache Pain. 2016 Dec;17(1):89. doi: 10.1186/s10194-016-0682-1. Epub 2016 Sep 
      26.