PMID- 27672065
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20220410
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 2
DP  - 2017 Feb
TI  - Balloon pulmonary angioplasty improves interventricular dyssynchrony in patients 
      with inoperable chronic thromboembolic pulmonary hypertension: a cardiac MR 
      imaging study.
PG  - 229-239
LID - 10.1007/s10554-016-0985-y [doi]
AB  - To use cardiac magnetic resonance imaging (MRI) to investigate the effect of 
      balloon pulmonary angioplasty (BPA) on interventricular dyssynchrony and its 
      associations with ventricular interaction, which impairs LV function in patients 
      with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). This 
      prospective observational study was approved by our institutional review board. 
      Cardiac MRI and right heart catheterization were conducted before BPA sessions 
      and at the follow up after BPA in 20 patients with CTEPH. We measured right 
      ventricular (RV) and left ventricular (LV) end-diastolic volume (EDV), 
      end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) using 
      MRI. For the LV and RV free walls, the time to peak (T(peak)) of circumferential 
      strain was calculated as a parameter for interventricular dyssynchrony. Following 
      BPA, the RV-EDV and -ESV were significantly decreased, and the RVEF was 
      significantly increased. Conversely, BPA led to significantly increased LV EDV 
      and SV without changing LVESV. The left-to-right free wall delay (L-R delay) in 
      T(peak) strain decreased from 105 +/- 44 ms to 47 +/- 67 ms (p < 0.001). Increased LV 
      EDV (r = 0.65, p < 0.01), SV (r = 0.74, p < 0.001) and 6-minute walk distance 
      (6MWD) (r = 0.54, p < 0.05) were correlated to the reduction in L-R delay. In 
      patients with inoperable CPEPH, BPA improved interventricular dyssynchrony, which 
      was strongly associated with increased SV and 6MWD. The assessment of 
      interventricular dyssynchrony using cardiac MRI has an important role in 
      evaluating ventricular interaction, which reduces LVSV and exercise tolerance.
FAU - Yamasaki, Yuzo
AU  - Yamasaki Y
AD  - Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. 
      yyama@radiol.med.kyushu-u.ac.jp.
FAU - Nagao, Michinobu
AU  - Nagao M
AD  - Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Abe, Kohtaro
AU  - Abe K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Hosokawa, Kazuya
AU  - Hosokawa K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Kawanami, Satoshi
AU  - Kawanami S
AD  - Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Kamitani, Takeshi
AU  - Kamitani T
AD  - Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
FAU - Yamanouchi, Torahiko
AU  - Yamanouchi T
AD  - Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
FAU - Horimoto, Koshin
AU  - Horimoto K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Yabuuchi, Hidetake
AU  - Yabuuchi H
AD  - Department of Health Sciences, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Honda, Hiroshi
AU  - Honda H
AD  - Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160926
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Vasodilator Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Angioplasty, Balloon/adverse effects
MH  - Antihypertensive Agents/therapeutic use
MH  - Chronic Disease
MH  - Exercise Tolerance
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/drug therapy/etiology/physiopathology
MH  - Linear Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Pulmonary Circulation
MH  - Pulmonary Embolism/complications/diagnostic imaging/physiopathology/*therapy
MH  - Recovery of Function
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vasodilator Agents/therapeutic use
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology
MH  - Ventricular Dysfunction, Right/*diagnostic imaging/etiology/physiopathology
MH  - *Ventricular Function, Left
MH  - *Ventricular Function, Right
MH  - Walk Test
OTO - NOTNLM
OT  - Balloon pulmonary angioplasty
OT  - Cardiac MRI
OT  - Chronic thromboembolic pulmonary hypertension
OT  - Interventricular dyssynchrony
EDAT- 2016/09/28 06:00
MHDA- 2017/09/12 06:00
CRDT- 2016/09/28 06:00
PHST- 2016/07/29 00:00 [received]
PHST- 2016/09/22 00:00 [accepted]
PHST- 2016/09/28 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2016/09/28 06:00 [entrez]
AID - 10.1007/s10554-016-0985-y [pii]
AID - 10.1007/s10554-016-0985-y [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 Feb;33(2):229-239. doi: 10.1007/s10554-016-0985-y. 
      Epub 2016 Sep 26.