PMID- 27672304
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160927
LR  - 20201001
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 10
DP  - 2016
TI  - Optic nerve head topography and retinal structural changes in eyes with 
      macrodisks: a comparative study with spectral domain optical coherence 
      tomography.
PG  - 1737-42
LID - 10.2147/OPTH.S102789 [doi]
AB  - PURPOSE: To compare optic nerve head parameters, the thicknesses of the 
      peripapillary retinal nerve fiber layer (pRNFL), the macular retinal nerve fiber 
      layer (mRNFL), the ganglion cell complex (GCC), and the ganglion cell-inner 
      plexiform layer (GCIPL) in macrodisks and normal-sized healthy disks using 
      spectral domain optical coherence tomography. PATIENTS AND METHODS: A total of 88 
      healthy eyes (42 macrodisks and 46 normal-sized disks) were prospectively 
      enrolled in the study. Optic nerve head parameters as well as pRNFL, mRNFL, GCC, 
      and GCIPL thicknesses were measured in all subjects. Optic disk areas (ODAs) 
      >2.70 mm(2) were defined as macrodisks. All spectral domain optical coherence 
      tomography parameters were compared between normal-sized disks and macrodisks. 
      RESULTS: The mean age of the participants was 49.4+/-5.7 years in the normal size 
      group and 51.55+/-6.3 years in the macrodisk group (P=0.65). The average ODAs were 
      2.23+/-0.29 mm(2) and 3.30+/-0.59 mm(2) in the normal size and the macrodisk groups, 
      respectively. ODA (P<0.001), cup area (P<0.001), cup disk area ratio (P<0.001), 
      horizontal cup disk ratio (P<0.001), vertical cup disk ratio (P<0.001), 
      horizontal disk diameter (P<0.001), vertical disk diameter (P<0.001), and cup 
      volume (P<0.001) were significantly higher in the macrodisk group. The inferior 
      mRNFL thickness was significantly lower (P=0.042), and the GCC inferior and GCIPL 
      inferior thicknesses were found to be lower with low significance (P=0.052, 
      P=0.059, respectively) in the macrodisk group. Rim volume (P=0.622), total pRNFL 
      (P=0.201), superior pRNFL (P=0.123), inferior pRNFL (P=0.168), average macular 
      thickness (P=0.162), total mRNFL (P=0.171), superior mRNFL (P=0.356), total GCC 
      (P=0.080), superior GCC (P=0.261), total GCIPL (P=0.214), and superior GCIPL 
      (P=0.515) thicknesses were similar in both groups. CONCLUSION: Optic disk 
      topography and retinal structures show different characteristics in healthy eyes 
      with macrodisks. These disk size-dependent variations suggest that large optic 
      disks may be more susceptible to glaucomatous damage.
FAU - Ozturker, Zeynep Kayaarasi
AU  - Ozturker ZK
AD  - Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, 
      Turkey.
FAU - Eltutar, Kadir
AU  - Eltutar K
AD  - Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, 
      Turkey.
FAU - Karini, Belma
AU  - Karini B
AD  - Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, 
      Turkey.
FAU - Erkul, Sezin Ozdogan
AU  - Erkul SO
AD  - Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, 
      Turkey.
FAU - Osmanbasoglu, Ozen Ayranci
AU  - Osmanbasoglu OA
AD  - Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, 
      Turkey.
FAU - Sultan, Pinar
AU  - Sultan P
AD  - Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160912
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC5026179
OTO - NOTNLM
OT  - ganglion cell complex
OT  - macrodisk
OT  - nerve fiber layer
OT  - optic nerve head
EDAT- 2016/09/28 06:00
MHDA- 2016/09/28 06:01
PMCR- 2016/09/12
CRDT- 2016/09/28 06:00
PHST- 2016/09/28 06:00 [entrez]
PHST- 2016/09/28 06:00 [pubmed]
PHST- 2016/09/28 06:01 [medline]
PHST- 2016/09/12 00:00 [pmc-release]
AID - opth-10-1737 [pii]
AID - 10.2147/OPTH.S102789 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2016 Sep 12;10:1737-42. doi: 10.2147/OPTH.S102789. eCollection 
      2016.