PMID- 27672636
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160927
LR  - 20201001
IS  - 2296-889X (Print)
IS  - 2296-889X (Electronic)
IS  - 2296-889X (Linking)
VI  - 3
DP  - 2016
TI  - Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts.
PG  - 53
LID - 10.3389/fmolb.2016.00053 [doi]
LID - 53
AB  - Melusin is a chaperone protein selectively expressed in heart and skeletal 
      muscles. Melusin expression levels correlate with cardiac function in 
      pre-clinical models and in human patients with aortic stenosis. Indeed, previous 
      studies in several animal models indicated that Melusin plays a broad 
      cardioprotective role in different pathological conditions. Chaperone proteins, 
      besides playing a role in protein folding, are also able to facilitate 
      supramolecular complex formation and conformational changes due to 
      activation/deactivation of signaling molecules. This role sets chaperone proteins 
      as crucial regulators of intracellular signal transduction pathways. In 
      particular Melusin activates AKT and ERK1/2 signaling, protects cardiomyocytes 
      from apoptosis and induces a compensatory hypertrophic response in several 
      pathological conditions. Therefore, selective delivery of the Melusin gene in 
      heart via cardiotropic adenoviral associated virus serotype 9 (AAV9), may 
      represent a new promising gene-therapy approach for different cardiac 
      pathologies.
FAU - Sorge, Matteo
AU  - Sorge M
AD  - Department of Molecular Biotechnology and Health Sciences, University of Torino 
      Torino, Italy.
FAU - Brancaccio, Mara
AU  - Brancaccio M
AD  - Department of Molecular Biotechnology and Health Sciences, University of Torino 
      Torino, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160912
PL  - Switzerland
TA  - Front Mol Biosci
JT  - Frontiers in molecular biosciences
JID - 101653173
PMC - PMC5018970
OTO - NOTNLM
OT  - AKT
OT  - ERK 1/2
OT  - HSP90
OT  - Melusin
OT  - apoptosis
OT  - chaperone
OT  - heart failure
OT  - intracellular signaling
EDAT- 2016/09/28 06:00
MHDA- 2016/09/28 06:01
PMCR- 2016/01/01
CRDT- 2016/09/28 06:00
PHST- 2016/06/17 00:00 [received]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/09/28 06:00 [entrez]
PHST- 2016/09/28 06:00 [pubmed]
PHST- 2016/09/28 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fmolb.2016.00053 [doi]
PST - epublish
SO  - Front Mol Biosci. 2016 Sep 12;3:53. doi: 10.3389/fmolb.2016.00053. eCollection 
      2016.