PMID- 27673483
OWN - NLM
STAT- MEDLINE
DCOM- 20170407
LR  - 20170817
IS  - 1524-4725 (Electronic)
IS  - 1076-0512 (Linking)
VI  - 43
IP  - 1
DP  - 2017 Jan
TI  - An 18-Month Follow-up, Randomized Comparison of Effectiveness and Safety of Two 
      Hyaluronic Acid Fillers for Treatment of Moderate Nasolabial Folds.
PG  - 58-65
LID - 10.1097/DSS.0000000000000923 [doi]
AB  - BACKGROUND: Hyaluronic acid (HA) filler injection is a popular nonsurgical 
      aesthetic procedure. OBJECTIVE: To compare the effectiveness and safety of 2 
      hyaluronic acid fillers (HAEC and HARES) for treatment of moderate nasolabial 
      folds (NLFs). MATERIALS AND METHODS: This was an evaluator- and subject-blinded 
      split-face study. HAEC or HARES was randomly assigned to the left or right NLF at 
      baseline. Retreatment was performed after 9 months; follow-up extended to 18 
      months after baseline (9 months after retreatment). Effectiveness assessments 
      included the Wrinkle Severity Rating Scale (WSRS) and subject preference. Safety 
      assessments included adverse events (AEs) and local tolerability symptoms 
      recorded by subjects during 3 weeks after treatment. RESULTS: HAEC was 
      noninferior to HARES measured as mean change from baseline in WSRS score at 6 
      months. Mean WSRS score change from baseline was similar between products up to 
      18 months. A majority of subjects (>70%) were still responders at 18 months 
      (after retreatment at 9 months). The volume required at retreatment was 
      approximately two-thirds of that at baseline. There was no difference in subject 
      preference between products. Both fillers were well tolerated and associated with 
      few treatment-related AEs. CONCLUSION: HAEC and HARES were effective and well 
      tolerated for treatment of moderate NLFs.
FAU - Rzany, Berthold
AU  - Rzany B
AD  - *RZANY & HUND, Privatpraxis, Berlin, Germany; daggerDepartment of Dermatology and 
      Allergology, HSK Wiesbaden, Lehrkrankenhaus der Universitat Mainz, Wiesbaden, 
      Germany; double daggerDepartment of Dermatology, Cannes Hospital, Cannes, France;  section signCentre 
      dermato-chirurgical et medecine de la nutrition, Bordeaux, France; 
       ||Dermatologische Praxis, Wuppertal, Germany;  paragraph signCPCAD, Hopital l'Archet 2, Nice, 
      France; #Gemeinschaftspraxis fur Dermatologie, Mahlow, Germany; **Praxis Dr. med. 
      Boris Sommer, Frankfurt, Germany; daggerdaggerGalderma, Uppsala, Sweden; double daggerdouble daggerDepartment of 
      Dermatology, Klinikum Darmstadt, Darmstadt, Germany.
FAU - Bayerl, Christiane
AU  - Bayerl C
FAU - Bodokh, Isaac
AU  - Bodokh I
FAU - Boineau, Dominique
AU  - Boineau D
FAU - Dirschka, Thomas
AU  - Dirschka T
FAU - Queille-Roussel, Catherine
AU  - Queille-Roussel C
FAU - Sebastian, Michael
AU  - Sebastian M
FAU - Sommer, Boris
AU  - Sommer B
FAU - Edwartz, Carolina
AU  - Edwartz C
FAU - Podda, Maurizio
AU  - Podda M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Dermatol Surg
JT  - Dermatologic surgery : official publication for American Society for Dermatologic 
      Surgery [et al.]
JID - 9504371
RN  - 0 (Dermal Fillers)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Dermal Fillers/adverse effects/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hyaluronic Acid/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - *Nasolabial Fold
MH  - Patient Preference
MH  - Retreatment
MH  - *Skin Aging
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2016/10/18 06:00
MHDA- 2017/04/08 06:00
CRDT- 2016/09/28 06:00
PHST- 2016/10/18 06:00 [pubmed]
PHST- 2017/04/08 06:00 [medline]
PHST- 2016/09/28 06:00 [entrez]
AID - 10.1097/DSS.0000000000000923 [doi]
PST - ppublish
SO  - Dermatol Surg. 2017 Jan;43(1):58-65. doi: 10.1097/DSS.0000000000000923.