PMID- 27676663
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20220311
IS  - 2150-1149 (Electronic)
IS  - 1533-3159 (Linking)
VI  - 19
IP  - 7
DP  - 2016 Sep-Oct
TI  - Tanshinone IIA Exerts an Antinociceptive Effect in Rats with Cancer-induced Bone 
      Pain.
PG  - 465-76
AB  - BACKGROUND: Cancer-induced bone pain (CIBP) is a common chronic pain 
      characterized by 2 components, ongoing pain and breakthrough pain. Tanshinone IIA 
      (TSN IIA) is a bioactive constituent of the traditional Chinese medicine Danshen, 
      which has been reported to have an antinociceptive effect on neuropathic and 
      inflammatory pain through downregulation of the late proinflammatory cytokine 
      high-mobility group protein B1 (HMGB1). OBJECTIVE: To assess the antinociceptive 
      effect of TSN IIA on CIBP. STUDY DESIGN: A randomized, double-blind, controlled 
      animal trial was performed. SETTING: University lab in China. METHODS: A rat CIBP 
      model was established by injecting Walker 256 mammary gland carcinoma cells into 
      the intramedullary cavity of the tibia. Both ongoing pain, e.g., flinching and 
      guarding, and breakthrough pain, e.g., limb use and von Frey threshold, were 
      evaluated. The effects of intraperitoneally administered TSN IIA on pain behavior 
      and the expression levels of spinal HMGB1, interleukin (IL)-1beta, tumor necrosis 
      factor (TNF)-alpha, and IL-6 were determined. The effect of TSN IIA on the 
      electrically evoked response of spinal wide-dynamic range (WDR) neurons was 
      performed in vivo. RESULTS: TSN IIA dose-dependently inhibited cancer-induced 
      ongoing pain and breakthrough pain. The expression levels of spinal HMGB1 and 
      other inflammatory factors (IL-1beta, TNF-alpha, and IL-6) were increased in the 
      rat model, but they were suppressed by TSN IIA in a dose-dependent manner. 
      Moreover, TSN IIA significantly inhibited the neuronal responses of WDR neurons 
      in spinal deep layers. LIMITATIONS: Further studies are warranted to ascertain 
      how TSN IIA attenuates cancer-induced ongoing pain. CONCLUSIONS: Our results 
      indicate that TSN IIA attenuates cancer-induced ongoing pain and breakthrough 
      pain, possibly via suppression of central sensitization in CIBP rats. Therefore, 
      we have provided strong evidence supporting TSN IIA as a potential and effective 
      therapy for relieving CIBP. KEY WORDS: Cancer-induced bone pain, high-mobility 
      group protein B1, Tanshinone IIA, ongoing pain, breakthrough pain.
FAU - Hao, Wei
AU  - Hao W
AD  - Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, Guangdong Province, 510280, China; Department of Anesthesiology, Inner 
      Mongolia People's Hospital, Hohhot, Inner Mongolia, 010017, China.
FAU - Chen, Lei
AU  - Chen L
FAU - Wu, Li-Fang
AU  - Wu LF
AD  - Department of Anesthesiology, the First Affiliated Hospital of Inner Mongolia 
      Medical University, Hohhot, Inner Mongolia , 010000, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Anesthesiology, the First Affiliated Hospital of Inner Mongolia 
      Medical University, Hohhot, Inner Mongolia , 010000, China.
FAU - Niu, Jian-Xiang
AU  - Niu JX
AD  - Department of C area of General Surgery, the First Affiliated Hospital of Inner 
      Mongolia Medical University, Hohhot, Inner Mongolia, 010000, China.
FAU - Kaye, Alan D
AU  - Kaye AD
FAU - Xu, Shi-Yuan
AU  - Xu SY
AD  - Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, Guangdong Province, 510280, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pain Physician
JT  - Pain physician
JID - 100954394
RN  - 0 (Abietanes)
RN  - 0 (Analgesics)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 03UUH3J385 (tanshinone)
SB  - IM
MH  - Abietanes/*therapeutic use
MH  - Analgesics
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Bone Neoplasms/*complications
MH  - China
MH  - Double-Blind Method
MH  - Pain/*drug therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2016/09/28 06:00
MHDA- 2017/07/25 06:00
CRDT- 2016/09/28 06:00
PHST- 2016/09/28 06:00 [entrez]
PHST- 2016/09/28 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PST - ppublish
SO  - Pain Physician. 2016 Sep-Oct;19(7):465-76.