PMID- 27679577
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160928
LR  - 20220318
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 7
DP  - 2016
TI  - Fluoxetine Ameliorates Atopic Dermatitis-Like Skin Lesions in BALB/c Mice through 
      Reducing Psychological Stress and Inflammatory Response.
PG  - 318
LID - 10.3389/fphar.2016.00318 [doi]
LID - 318
AB  - Atopic dermatitis (AD) is a common chronic inflammatory skin disorder, and 
      patients with AD suffer from severe psychological stress, which markedly 
      increases the prevalence rate of depression and anxiety disorders in later life. 
      Fluoxetine, a selective serotonin reuptake inhibitor, has recently been reported 
      to exert anti-inflammatory and immunosuppressive effects. However, it is unclear 
      whether fluoxetine is effective in the treatment of AD through reducing 
      psychological stress and inflammatory reaction. Here, we reported that a BALB/c 
      mouse model of AD was induced by application of 2,4-dinitrochlorobenzene (DNCB) 
      onto hairless dorsal skin. Chronic fluoxetine treatment (10 mg/kg per day, i.p.) 
      significantly attenuated AD-like symptoms, as reflected by a dramatic decrease in 
      scratching bouts, as well as a decrease in anxiety- and depressive-like 
      behaviors. Furthermore, these behavioral changes were accompanied by a 
      significant decrease in epidermal thickness, the number of mast cells in skin 
      tissue, mRNA levels of interleukin-4 (IL-4) and IL-13 in the spleen, as well as 
      serum immunoglobulin E (IgE) in the DNCB-treated mice by treatment with 
      fluoxetine. Taken together, these results indicate that fluoxetine may suppress 
      psychological stress and inflammatory response during AD development, and 
      subsequently ameliorate AD symptoms, suggesting that fluoxetine may be a 
      potential therapeutic agent against AD in clinic.
FAU - Li, Yanxi
AU  - Li Y
AD  - Chongqing Key Laboratory of Translational Medical Research in Cognitive 
      Development and Learning and Memory Disorders, Children's Hospital of Chongqing 
      Medical UniversityChongqing, China; Ministry of Education Key Laboratory of Child 
      Development and Disorders, Children's Hospital of Chongqing Medical 
      UniversityChongqing, China; The Chongqing Hospital of Traditional Chinese 
      MedicineChongqing, China.
FAU - Chen, Long
AU  - Chen L
AD  - Chongqing Key Laboratory of Translational Medical Research in Cognitive 
      Development and Learning and Memory Disorders, Children's Hospital of Chongqing 
      Medical UniversityChongqing, China; Ministry of Education Key Laboratory of Child 
      Development and Disorders, Children's Hospital of Chongqing Medical 
      UniversityChongqing, China.
FAU - Du, Yehong
AU  - Du Y
AD  - Chongqing Key Laboratory of Translational Medical Research in Cognitive 
      Development and Learning and Memory Disorders, Children's Hospital of Chongqing 
      Medical UniversityChongqing, China; Ministry of Education Key Laboratory of Child 
      Development and Disorders, Children's Hospital of Chongqing Medical 
      UniversityChongqing, China.
FAU - Huang, Daochao
AU  - Huang D
AD  - Chongqing Key Laboratory of Translational Medical Research in Cognitive 
      Development and Learning and Memory Disorders, Children's Hospital of Chongqing 
      Medical UniversityChongqing, China; Ministry of Education Key Laboratory of Child 
      Development and Disorders, Children's Hospital of Chongqing Medical 
      UniversityChongqing, China.
FAU - Han, Huili
AU  - Han H
AD  - Chongqing Key Laboratory of Translational Medical Research in Cognitive 
      Development and Learning and Memory Disorders, Children's Hospital of Chongqing 
      Medical UniversityChongqing, China; Ministry of Education Key Laboratory of Child 
      Development and Disorders, Children's Hospital of Chongqing Medical 
      UniversityChongqing, China.
FAU - Dong, Zhifang
AU  - Dong Z
AD  - Chongqing Key Laboratory of Translational Medical Research in Cognitive 
      Development and Learning and Memory Disorders, Children's Hospital of Chongqing 
      Medical UniversityChongqing, China; Ministry of Education Key Laboratory of Child 
      Development and Disorders, Children's Hospital of Chongqing Medical 
      UniversityChongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20160913
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC5020056
OTO - NOTNLM
OT  - anti-inflammation
OT  - atopic dermatitis
OT  - fluoxetine
OT  - itching
OT  - psychological stress
EDAT- 2016/09/30 06:00
MHDA- 2016/09/30 06:01
PMCR- 2016/09/13
CRDT- 2016/09/29 06:00
PHST- 2016/07/12 00:00 [received]
PHST- 2016/09/02 00:00 [accepted]
PHST- 2016/09/29 06:00 [entrez]
PHST- 2016/09/30 06:00 [pubmed]
PHST- 2016/09/30 06:01 [medline]
PHST- 2016/09/13 00:00 [pmc-release]
AID - 10.3389/fphar.2016.00318 [doi]
PST - epublish
SO  - Front Pharmacol. 2016 Sep 13;7:318. doi: 10.3389/fphar.2016.00318. eCollection 
      2016.