PMID- 27680963
OWN - NLM
STAT- MEDLINE
DCOM- 20170519
LR  - 20170519
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 116
IP  - 8
DP  - 2016 Oct
TI  - Prenatal food restriction induces poor-quality articular cartilage in female rat 
      offspring fed a post-weaning high-fat diet and its intra-uterine programming 
      mechanisms.
PG  - 1346-1355
AB  - Epidemiological data show that osteoarthritis (OA) is significantly associated 
      with lower birth weight, and that OA may be a type of fetal-originated adult 
      disease. The present study aimed to investigate the prenatal food-restriction 
      (PFR) effect on the quality of articular cartilage in female offspring to explore 
      the underlying mechanisms of fetal-originated OA. Maternal rats were fed a 
      restricted diet from gestational day (GD) 11 to 20 to induce intra-uterine growth 
      retardation. Female fetuses and female adult offspring fed a post-weaning 
      high-fat diet were killed at GD20 and postnatal week 24, respectively. Serum and 
      knee cartilage samples from fetuses and adult female offspring were collected and 
      examined for cholesterol metabolism and histology. Fetal serum corticosterone and 
      insulin-like growth factor-1 (IGF-1) in the PFR group were lower than those of 
      the control, but the serum cholesterol level was not changed. The lower 
      expression of IGF-1 in the PFR group lasted into adulthood. The expression of 
      extracellular matrix (ECM) genes, including type II collagen, aggrecan and 
      cholesterol efflux genes including liver X receptor, were significantly induced, 
      but the ATP-binding-cassette transporter A1 was unchanged. PFR could induce a 
      reduction in ECM synthesis and impaired cholesterol efflux in female offspring, 
      and eventually led to poor quality of articular cartilage and OA.
FAU - Tan, Yang
AU  - Tan Y
AD  - 1Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Wu, Yunpeng
AU  - Wu Y
AD  - 1Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Ni, Qubo
AU  - Ni Q
AD  - 1Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Deng, Yu
AU  - Deng Y
AD  - 1Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Li, Jing
AU  - Li J
AD  - 3Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Wang, Linlong
AU  - Wang L
AD  - 1Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Shen, Lang
AU  - Shen L
AD  - 3Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Liu, Yansong
AU  - Liu Y
AD  - 3Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Magdalou, Jacques
AU  - Magdalou J
AD  - 4Universite de Lorraine,Ingenierie Moleculaire, Physiopathologie Articulaire 
      (IMoPA),UMR 7365 CNRS,Biopole,F-54505 Vandoeuvre-les-Nancy,France.
FAU - Wang, Hui
AU  - Wang H
AD  - 3Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 
      430071,People's Republic of China.
FAU - Chen, Liaobin
AU  - Chen L
AD  - 1Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 
      430071,People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20160929
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (insulin-like growth factor-1, rat)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Caloric Restriction/adverse effects
MH  - Cartilage Diseases/embryology/*etiology/metabolism/pathology
MH  - Cartilage, Articular/embryology/metabolism/*pathology
MH  - Cholesterol/blood/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - *Disease Models, Animal
MH  - Dyslipidemias/etiology/physiopathology
MH  - Extracellular Matrix Proteins/genetics/*metabolism
MH  - Female
MH  - *Fetal Development
MH  - Fetal Growth Retardation/etiology/*physiopathology
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Developmental
MH  - Insulin-Like Growth Factor I/analysis
MH  - Maternal Nutritional Physiological Phenomena
MH  - Osteoarthritis, Knee/embryology/*etiology/metabolism/pathology
MH  - Pregnancy
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Specific Pathogen-Free Organisms
MH  - Weaning
OTO - NOTNLM
OT  - ABCA1 ATP-binding-cassette transporter A1
OT  - Col2a1 collagen type II alpha1
OT  - GC glucocorticoids
OT  - GD gestational day
OT  - HFD high-fat diet
OT  - IGF-1 insulin-like growth factor-1
OT  - IUGR intra-uterine growth retardation
OT  - LXR liver X receptor
OT  - MS metabolic syndrome
OT  - OA osteoarthritis
OT  - PFR prenatal food-restriction
OT  - Articular cartilage
OT  - Cholesterol
OT  - Glucocorticoids
OT  - Insulin-like growth factor-1
OT  - Prenatal food restriction
EDAT- 2016/10/22 06:00
MHDA- 2017/05/20 06:00
CRDT- 2016/09/30 06:00
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2017/05/20 06:00 [medline]
PHST- 2016/09/30 06:00 [entrez]
AID - S000711451600338X [pii]
AID - 10.1017/S000711451600338X [doi]
PST - ppublish
SO  - Br J Nutr. 2016 Oct;116(8):1346-1355. doi: 10.1017/S000711451600338X. Epub 2016 
      Sep 29.