PMID- 27682427
OWN - NLM
STAT- MEDLINE
DCOM- 20170403
LR  - 20191210
IS  - 1748-717X (Electronic)
IS  - 1748-717X (Linking)
VI  - 11
IP  - 1
DP  - 2016 Sep 29
TI  - Hyperbaric oxygen therapy for late radiation-induced tissue toxicity: 
      prospectively patient-reported outcome measures in breast cancer patients.
PG  - 130
LID - 130
AB  - INTRODUCTION: This study examines patient reported outcome measures of women 
      undergoing hyperbaric oxygen treatment (HBOT) after breast-conserving therapy. 
      METHOD: Included were 57 women treated with HBOT for late radiation-induced 
      tissue toxicity (LRITT) referred in the period January 2014-December 2015. HBOT 
      consisted of (on average) 47 sessions. In total, 80 min of 100 % O(2) was 
      administered under increased pressure of 2.4 ATA. Quality of life was assessed 
      before and after treatment using the European Organization for Research and 
      Treatment of Cancer (EORTC) QLQ-BR23, and a NRS pain score. RESULTS: Fifty-seven 
      women were available for evaluation before and after treatment. Before HBOT, 
      patients had severe complaints of pain in the arm/shoulder (46 %), swollen 
      arm/hand (14 %), difficulty to raise arm or move it sideways (45 %), pain in the 
      area of the affected breast (67 %), swollen area of the affected breast (45 %), 
      oversensitivity of the affected breast (54 %), and skin problems on/in the area 
      of the affected breast (32 %); post HBOT, severe complaints were still 
      experienced in 17, 7, 22, 15, 13, 15, and 11 % of the women, respectively. 
      Differences were all significant. The NRS pain score improved at least 1 point 
      (range 0-10) in 81 % of the patients (p < 0.05). CONCLUSION: In these breast 
      cancer patients treated with HBOT for LRITT, the patient-reported outcomes were 
      positive and improvements were observed. HBOT was a well-tolerated treatment for 
      LRITT and its side-effects were both minimal and reversible.
FAU - Teguh, David N
AU  - Teguh DN
AUID- ORCID: 0000-0002-1108-7389
AD  - Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The 
      Netherlands. d.teguh@hgcrijswijk.nl.
AD  - Department of Surgery/Hyperbaric Medicine, Academic Medical Center, University of 
      Amsterdam, Amsterdam, The Netherlands. d.teguh@hgcrijswijk.nl.
FAU - Bol Raap, Rene
AU  - Bol Raap R
AD  - Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The 
      Netherlands.
FAU - Struikmans, Henk
AU  - Struikmans H
AD  - Department of Radiation Oncology, Leiden University Medical Centre, Leiden, The 
      Netherlands.
AD  - Radiotherapy Centre West, Medical Centre Haaglanden, The Hague, The Netherlands.
FAU - Verhoef, Cees
AU  - Verhoef C
AD  - Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The 
      Netherlands.
FAU - Koppert, Linetta B
AU  - Koppert LB
AD  - Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The 
      Netherlands.
FAU - Koole, Arne
AU  - Koole A
AD  - Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The 
      Netherlands.
FAU - Huang, Yadi
AU  - Huang Y
AD  - University of Leuven, Leuven, The Netherlands.
FAU - van Hulst, Rob A
AU  - van Hulst RA
AD  - Hyperbaar Geneeskundig Centrum Rijswijk, Treubstraat 5a, 2288 EG, Rijswijk, The 
      Netherlands.
AD  - Department of Anesthesiology/Hyperbaric Medicine, Academic Medical Center, 
      University of Amsterdam, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20160929
PL  - England
TA  - Radiat Oncol
JT  - Radiation oncology (London, England)
JID - 101265111
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/psychology/*radiotherapy
MH  - Europe
MH  - Female
MH  - Fibrosis/physiopathology
MH  - Humans
MH  - Hyperbaric Oxygenation/*methods
MH  - Mastectomy, Segmental
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Oxygen/therapeutic use
MH  - *Patient Reported Outcome Measures
MH  - Quality of Life
MH  - Radiation Injuries/physiopathology/psychology/*therapy
MH  - Radiotherapy/*adverse effects
MH  - Self Report
MH  - Surveys and Questionnaires
PMC - PMC5041335
OTO - NOTNLM
OT  - Breast cancer
OT  - Fibrosis
OT  - Pain
OT  - Radiation toxicity
OT  - Radiotherapy
EDAT- 2016/09/30 06:00
MHDA- 2017/04/04 06:00
PMCR- 2016/09/29
CRDT- 2016/09/30 06:00
PHST- 2016/05/14 00:00 [received]
PHST- 2016/09/13 00:00 [accepted]
PHST- 2016/09/30 06:00 [pubmed]
PHST- 2017/04/04 06:00 [medline]
PHST- 2016/09/30 06:00 [entrez]
PHST- 2016/09/29 00:00 [pmc-release]
AID - 10.1186/s13014-016-0700-0 [pii]
AID - 700 [pii]
AID - 10.1186/s13014-016-0700-0 [doi]
PST - epublish
SO  - Radiat Oncol. 2016 Sep 29;11(1):130. doi: 10.1186/s13014-016-0700-0.