PMID- 27683073 OWN - NLM STAT- MEDLINE DCOM- 20180905 LR - 20180905 IS - 1600-0501 (Electronic) IS - 0905-7161 (Linking) VI - 28 IP - 10 DP - 2017 Oct TI - Monophasic ss-TCP vs. biphasic HA/ss-TCP in two-stage sinus floor augmentation procedures - a prospective randomized clinical trial. PG - e175-e183 LID - 10.1111/clr.12983 [doi] AB - OBJECTIVES: To compare a monophasic (100% ss-TCP) and a biphasic (60% HA and 40% ss-TCP) bone substitute material (BSM) regarding biocompatibility, osteoconductivity and implant stability using histological, radiological and resonance frequency analysis. MATERIAL AND METHODS: Sixty-seven sinus floor elevations were performed in 60 patients. One patient group (monophasic bone substitute [MBS], 30 patients, 32 sinuses) was augmented by the use of the monophasic material (Bioresorb((R)) , Sybron Implant Solutions, Bremen, Germany), while the second group (biphasic bone substitute (BBS), 30 patients, 35 sinuses) received a biphasic material (Maxresorb((R)) , Botiss Biomaterials, Berlin, Germany). Cone beam CT images were taken immediately after augmentation and prior to implant placement after 6 months. Trephines were harvested, while the implant bed was prepared. Resonance frequency analysis was performed immediately after implant placement and 6 months later. Descriptive analysis was performed on all augmented sinus (n = 67). For statistical comparison of the groups, one sinus of each bilaterally treated patient was randomly excluded, resulting in 30 sinuses grafted with MBS and 30 sinuses grafted with BBS (n = 60). RESULTS: Histomorphometrical analysis of all sinuses displayed comparable results for both groups regarding new bone matrix (MBS 36.16 +/- 19.37%, BBS 38.42 +/- 12.61%), residual BSM (MBS 30.26 +/- 11.7%, BBS 32.66 +/- 12.57%) and non-mineralized tissue (MBS 34.29 +/- 18.32%, BBS 28.92 +/- 15.04) %) (P > 0.05, respectively). Radiological volume of BBS was significantly more stable (volume loss of 22.2% for MBS, 6.66% for BBS; P < 0.001), and homogeneity of the graft after 6 months was higher for BBS than that for MBS (P < 0.05). Resonance frequency analysis endorsed a higher implant stability quotient for BBS after 6 months than that for MBS (MBS 78.31 +/- 5.81, BBS 80.42 +/- 6.31; P < 0.05, Mann-Whitney U-test, respectively). CONCLUSION: Both monophasic and biphasic materials show good biocompatibility and osteoconductivity with satisfactory support on implant stability. BBS remains more stable in terms of volume maintenance and radiological graft homogeneity after a healing period of 6 months. CI - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Jelusic, Damir AU - Jelusic D AD - Private Practice, Opatja, Croatia. FAU - Zirk, Matthias L AU - Zirk ML AD - Department of Craniomaxillofacial and Plastic Surgery, University Hospital of Cologne, Cologne, Germany. FAU - Fienitz, Tim AU - Fienitz T AD - Department of Craniomaxillofacial and Plastic Surgery, University Hospital of Cologne, Cologne, Germany. FAU - Plancak, Darije AU - Plancak D AD - Department of Periodontology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia. FAU - Puhar, Ivan AU - Puhar I AD - Department of Periodontology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia. FAU - Rothamel, Daniel AU - Rothamel D AD - Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Heinrich Heine University Duesseldorf, Duesseldorf, Germany. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20160929 PL - Denmark TA - Clin Oral Implants Res JT - Clinical oral implants research JID - 9105713 RN - 0 (Biocompatible Materials) RN - 0 (Calcium Phosphates) RN - 0 (beta-tricalcium phosphate) RN - 91D9GV0Z28 (Durapatite) MH - Biocompatible Materials/*administration & dosage MH - Bone Regeneration MH - Calcium Phosphates/*administration & dosage MH - Durapatite/*administration & dosage MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - Sinus Floor Augmentation/*methods OTO - NOTNLM OT - augmentation OT - biphasic OT - bone substitute OT - hydroxyapatite OT - implantology OT - sinus lift OT - beta-tricalcium phosphate EDAT- 2016/09/30 06:00 MHDA- 2018/09/06 06:00 CRDT- 2016/09/30 06:00 PHST- 2016/08/27 00:00 [accepted] PHST- 2016/09/30 06:00 [pubmed] PHST- 2018/09/06 06:00 [medline] PHST- 2016/09/30 06:00 [entrez] AID - 10.1111/clr.12983 [doi] PST - ppublish SO - Clin Oral Implants Res. 2017 Oct;28(10):e175-e183. doi: 10.1111/clr.12983. Epub 2016 Sep 29.