PMID- 27684846
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20181113
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 39
DP  - 2016 Sep
TI  - Clinical significance of hyperhomocysteinemia in infective endocarditis: A 
      case-control study.
PG  - e4972
LID - 10.1097/MD.0000000000004972 [doi]
LID - e4972
AB  - Blood coagulation plays a key role in the pathogenesis of infective endocarditis 
      (IE). Conditions associated with thrombophilia could enhance IE vegetation 
      formation and promote embolic complications.In this study, we assessed 
      prevalence, correlates, and clinical consequences of hyper-homocysteinemia 
      (h-Hcy) in IE.Homocysteine (Hcy) plasma levels were studied in 246 IE patients 
      and 258 valvular heart disease (VHD) patients, as well as in 106 healthy 
      controls.IE patients showed Hcy levels comparable to VHD patients (14.9 [3-81] vs 
      16 [5-50] mumol/L, respectively; P = 0.08). H-Hcy was observed in 48.8% of IE 
      patients and 55.8% of VHD (P = 0.13). Vegetation size and major embolic 
      complications were not related to Hcy levels. IE patients with h-Hcy had a higher 
      prevalence of chronic kidney disease and a higher 1-year mortality (19.6% vs 9.9% 
      in those without h-Hcy; OR 2.21 [1.00-4.89], P = 0.05). However, at logistic 
      regression analysis, h-Hcy was not an independent predictor of 1-year mortality 
      (OR 1.87 [95% CI 0.8-4.2]; P = 0.13).Our data suggest h-Hcy in IE is common, is 
      related to a worse renal function, and may be a marker of cardiac dysfunction 
      rather than infection. H-Hcy does not appear to favor IE vegetation formation or 
      its symptomatic embolic complications.
FAU - Iossa, Domenico
AU  - Iossa D
AD  - aInternal Medicine Section, Department of Cardiothoracic Sciences, University of 
      Naples S.U.N. bUnit of Infectious & Transplant Medicine cUnit of Clinical 
      Biochemistry dUnit of Cardiac Surgery A.O.R.N. dei Colli - Ospedale Monaldi, 
      Napoli, Italy.
FAU - Molaro, Rosa
AU  - Molaro R
FAU - Andini, Roberto
AU  - Andini R
FAU - Parrella, Antonio
AU  - Parrella A
FAU - Ursi, Maria Paola
AU  - Ursi MP
FAU - Mattucci, Irene
AU  - Mattucci I
FAU - De Vincentiis, Lucia
AU  - De Vincentiis L
FAU - Dialetto, Giovanni
AU  - Dialetto G
FAU - Utili, Riccardo
AU  - Utili R
FAU - Durante-Mangoni, Emanuele
AU  - Durante-Mangoni E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Endocarditis/blood/*complications
MH  - Female
MH  - Heart Valve Diseases/blood/complications
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/epidemiology/*etiology
MH  - Kidney Failure, Chronic/etiology/mortality
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Young Adult
PMC - PMC5265939
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/09/30 06:00
MHDA- 2017/02/18 06:00
PMCR- 2016/09/30
CRDT- 2016/09/30 06:00
PHST- 2016/09/30 06:00 [entrez]
PHST- 2016/09/30 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
PHST- 2016/09/30 00:00 [pmc-release]
AID - 00005792-201609270-00056 [pii]
AID - 10.1097/MD.0000000000004972 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Sep;95(39):e4972. doi: 10.1097/MD.0000000000004972.