PMID- 27686175
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20170817
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 146
IP  - 4
DP  - 2016 Oct
TI  - Spindle Cell Lipomas Arising at Atypical Locations.
PG  - 487-95
LID - 10.1093/ajcp/aqw137 [doi]
AB  - OBJECTIVES: Spindle cell lipomas (SCLs) are benign lipomatous neoplasms that 
      classically arise in the posterior neck, upper back, and shoulders of older male 
      patients. We sought to characterize the occurrence of this entity at nonclassic 
      sites. METHODS: All cases of SCL arising at atypical sites were retrieved from 
      our archives. RESULTS: Of 439 total cases of SCL, 57 arose at atypical locations 
      in 32 men and 25 women (age range, 27-79 years). The tumor sites included leg 
      (n = 23), buttock/perineum/inguinal (n = 10), forearm (n = 9), finger (n = 9), 
      foot (n = 2), toe (n = 2), hand (n = 1), and flank (n = 1). CD34 was positive 
      staining in all cases tested (52/52), while desmin was negative in most tumors 
      (48/50). Thirty-eight of 38 cases tested exhibited loss of Rb expression. No 
      cases showed CPM/MDM2 amplification (0/48). No local recurrences have been 
      reported (n = 39). CONCLUSIONS: SCLs may arise in the trunk, lower extremities, 
      and distal upper extremities. While most SCLs arising in classic sites occur in 
      male patients, there is a relatively equal sex distribution in tumors at atypical 
      sites. Pathologists should be aware that SCLs arise at atypical locations to 
      avoid misclassification as other lipomatous neoplasms, including atypical 
      lipomatous tumor.
CI  - (c) American Society for Clinical Pathology, 2016. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Ud Din, Nasir
AU  - Ud Din N
AD  - From the Department of Pathology and Laboratory Medicine, Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Zhang, Pingchuan
AU  - Zhang P
AD  - Department of Laboratory Medicine and Pathology.
FAU - Sukov, William R
AU  - Sukov WR
AD  - Department of Laboratory Medicine and Pathology.
FAU - Sattler, Christopher A
AU  - Sattler CA
AD  - Department of Laboratory Medicine and Pathology.
FAU - Jenkins, Sarah M
AU  - Jenkins SM
AD  - Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
FAU - Doyle, Leona A
AU  - Doyle LA
AD  - Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, 
      Boston, MA.
FAU - Folpe, Andrew L
AU  - Folpe AL
AD  - Department of Laboratory Medicine and Pathology.
FAU - Fritchie, Karen J
AU  - Fritchie KJ
AD  - Department of Laboratory Medicine and Pathology fritchie.karen@mayo.edu.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Buttocks/*pathology
MH  - Female
MH  - Foot/*pathology
MH  - Forearm/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Leg/*pathology
MH  - Lipoma/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Soft Tissue Neoplasms/metabolism/*pathology
MH  - Torso/*pathology
OTO - NOTNLM
OT  - Lipoma
OT  - MDM2
OT  - Rb
OT  - Spindle cell lipoma
EDAT- 2016/10/01 06:00
MHDA- 2017/02/28 06:00
CRDT- 2016/10/01 06:00
PHST- 2016/10/01 06:00 [entrez]
PHST- 2016/10/01 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
AID - aqw137 [pii]
AID - 10.1093/ajcp/aqw137 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2016 Oct;146(4):487-95. doi: 10.1093/ajcp/aqw137.