PMID- 27686734
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 16
IP  - 1
DP  - 2016 Sep 29
TI  - Single-dose acarbose decreased glucose-dependent insulinotropic peptide and 
      glucagon levels in Chinese patients with newly diagnosed type 2 diabetes mellitus 
      after a mixed meal.
PG  - 55
LID - 55
AB  - BACKGROUND: Acarbose slows down the intestinal absorption of carbohydrates, but 
      its effects on the secretion of incretins are still poorly known. This study 
      aimed to examine the effects of single-dose acarbose on the secretion of 
      incretins in patients with newly diagnosed type 2 diabetes mellitus (T2DM). 
      METHODS: In this pilot study, twenty-three patients diagnosed with T2DM were 
      randomly assigned to the oral glucose tolerance test (OGTT) group (n = 11) and 
      the mixed meal test (MMT) group (n = 12). Fourteen subjects with normal OGTT were 
      included as controls. Plasma glucose, insulin, glucagon, glucagon-like peptide-1 
      (GLP-1), and glucose-dependent insulinotropic peptide (GIP) were measured at 0 
      (fasting), 15, 30, 60, 90, and 120 min after nutrient load. A week later, 
      controls underwent MMT, the OGTT group underwent OGTT receiving 100 mg acarbose, 
      and the MMT group underwent MMT receiving 100 mg acarbose. The same blood markers 
      were measured again. RESULTS: No significant difference was observed in the OGTT 
      group before and after administering acarbose. In the MMT group, postprandial 
      levels of glucose (P < 0.01), insulin (P < 0.01), glucagon at 15 min (P < 0.05), 
      glucagon area under the curve (AUC) (P < 0.05), GIP levels at 30 min (P < 0.05), 
      and GIP AUC (P < 0.05) were decreased after receiving acarbose with a mixed meal, 
      but GLP-1 levels and GLP-1 AUC did not change. CONCLUSIONS: Single-dose acarbose 
      could reduce the secretion of GIP and glucagon after a mixed meal in patients 
      with newly diagnosed T2DM. The influence of acarbose on incretin levels could be 
      related to the types of carbohydrate being consumed. TRIAL REGISTRATION: This 
      study was registered with the Chinese Clinical Trial Registry (Registration 
      Number: ChiCTR-TRC-14004260 , Date of Registration: 2014-01-19).
FAU - Chen, Zhong
AU  - Chen Z
AD  - Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of 
      Medical Sciences, Guangzhou, 510080, Guangdong, China.
FAU - Fu, Xiaoying
AU  - Fu X
AD  - Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of 
      Medical Sciences, Guangzhou, 510080, Guangdong, China.
FAU - Kuang, Jian
AU  - Kuang J
AD  - Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of 
      Medical Sciences, Guangzhou, 510080, Guangdong, China. jkuang780@sina.com.
FAU - Chen, Ju
AU  - Chen J
AD  - Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of 
      Medical Sciences, Guangzhou, 510080, Guangdong, China.
FAU - Chen, Hongmei
AU  - Chen H
AD  - Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of 
      Medical Sciences, Guangzhou, 510080, Guangdong, China.
FAU - Pei, Jianhao
AU  - Pei J
AD  - Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of 
      Medical Sciences, Guangzhou, 510080, Guangdong, China.
FAU - Yang, Huazhang
AU  - Yang H
AD  - Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of 
      Medical Sciences, Guangzhou, 510080, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20160929
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
PMC - PMC5041397
OTO - NOTNLM
OT  - Acarbose
OT  - Glucagon
OT  - Glucagon-like peptide-1
OT  - Glucose-dependent insulinotropic peptide
OT  - Type 2 diabetes mellitus
EDAT- 2016/10/01 06:00
MHDA- 2016/10/01 06:00
PMCR- 2016/09/29
CRDT- 2016/10/01 06:00
PHST- 2016/01/19 00:00 [received]
PHST- 2016/09/21 00:00 [accepted]
PHST- 2016/10/01 06:00 [entrez]
PHST- 2016/10/01 06:00 [pubmed]
PHST- 2016/10/01 06:00 [medline]
PHST- 2016/09/29 00:00 [pmc-release]
AID - 10.1186/s12902-016-0133-7 [pii]
AID - 133 [pii]
AID - 10.1186/s12902-016-0133-7 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2016 Sep 29;16(1):55. doi: 10.1186/s12902-016-0133-7.