PMID- 27689896
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20181202
IS  - 1361-8423 (Electronic)
IS  - 1361-8415 (Linking)
VI  - 35
DP  - 2017 Jan
TI  - Atlas-based shape analysis and classification of retinal optical coherence 
      tomography images using the functional shape (fshape) framework.
PG  - 570-581
LID - S1361-8415(16)30160-8 [pii]
LID - 10.1016/j.media.2016.08.012 [doi]
AB  - We propose a novel approach for quantitative shape variability analysis in 
      retinal optical coherence tomography images using the functional shape (fshape) 
      framework. The fshape framework uses surface geometry together with functional 
      measures, such as retinal layer thickness defined on the layer surface, for 
      registration across anatomical shapes. This is used to generate a population mean 
      template of the geometry-function measures from each individual. Shape 
      variability across multiple retinas can be measured by the geometrical 
      deformation and functional residual between the template and each of the 
      observations. To demonstrate the clinical relevance and application of the 
      framework, we generated atlases of the inner layer surface and layer thickness of 
      the Retinal Nerve Fiber Layer (RNFL) of glaucomatous and normal subjects, 
      visualizing detailed spatial pattern of RNFL loss in glaucoma. Additionally, a 
      regularized linear discriminant analysis classifier was used to automatically 
      classify glaucoma, glaucoma-suspect, and control cases based on RNFL fshape 
      metrics.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Lee, Sieun
AU  - Lee S
AD  - School of Engineering Science, Simon Fraser University, Burnaby, British 
      Columbia, V5A 1S6, Canada.
FAU - Charon, Nicolas
AU  - Charon N
AD  - Center for Imaging Sciences (CIS), Johns Hopkins University, Baltimore, MD 21218, 
      USA.
FAU - Charlier, Benjamin
AU  - Charlier B
AD  - Institut Montpellierain Alexander Grothendieck, Campus Triolet, Montpellier 
      34095, France.
FAU - Popuri, Karteek
AU  - Popuri K
AD  - School of Engineering Science, Simon Fraser University, Burnaby, British 
      Columbia, V5A 1S6, Canada.
FAU - Lebed, Evgeniy
AU  - Lebed E
AD  - School of Engineering Science, Simon Fraser University, Burnaby, British 
      Columbia, V5A 1S6, Canada.
FAU - Sarunic, Marinko V
AU  - Sarunic MV
AD  - School of Engineering Science, Simon Fraser University, Burnaby, British 
      Columbia, V5A 1S6, Canada.
FAU - Trouve, Alain
AU  - Trouve A
AD  - CMLA, ENS Cachan, CNRS, Universite Paris-Saclay, Cachan 94235, France.
FAU - Beg, Mirza Faisal
AU  - Beg MF
AD  - School of Engineering Science, Simon Fraser University, Burnaby, British 
      Columbia, V5A 1S6, Canada. Electronic address: mfbeg@sfu.ca.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
DEP - 20160920
PL  - Netherlands
TA  - Med Image Anal
JT  - Medical image analysis
JID - 9713490
SB  - IM
MH  - Algorithms
MH  - Atlases as Topic
MH  - Case-Control Studies
MH  - Glaucoma/diagnostic imaging/pathology
MH  - Humans
MH  - Retina/anatomy & histology/*diagnostic imaging
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Fields
OTO - NOTNLM
OT  - Atlas generation
OT  - Atlas-based shape analysis
OT  - Classification
OT  - Computational anatomy
OT  - Optical coherence tomography
EDAT- 2016/10/01 06:00
MHDA- 2018/04/17 06:00
CRDT- 2016/10/01 06:00
PHST- 2015/10/27 00:00 [received]
PHST- 2016/08/27 00:00 [revised]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/10/01 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2016/10/01 06:00 [entrez]
AID - S1361-8415(16)30160-8 [pii]
AID - 10.1016/j.media.2016.08.012 [doi]
PST - ppublish
SO  - Med Image Anal. 2017 Jan;35:570-581. doi: 10.1016/j.media.2016.08.012. Epub 2016 
      Sep 20.