PMID- 27690324 OWN - NLM STAT- MEDLINE DCOM- 20171023 LR - 20180105 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 45 IP - 5 DP - 2017 May TI - T(Rho) and magnetization transfer and INvErsion recovery (TRAMINER)-prepared imaging: A novel contrast-enhanced flow-independent dark-blood technique for the evaluation of myocardial late gadolinium enhancement in patients with myocardial infarction. PG - 1429-1437 LID - 10.1002/jmri.25498 [doi] AB - PURPOSE: To evaluate a new dark-blood late gadolinium enhancement (LGE) technique called "T(Rho) And Magnetization transfer and INvErsion Recovery" (TRAMINER) for the ability to detect myocardial LGE versus standard "bright-blood" inversion recovery (SIR) imaging. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant prospective study included 40 patients (62 +/- 14 years [mean +/- standard deviation (SD)], 29 males) with suspected myocardial infarction (MI) referred for the assessment of myocardial viability. The patients underwent a 1.5T cardiac magnetic resonance imaging (MRI) including postcontrast SIR and TRAMINER acquisitions. Normalized images were evaluated by two readers. Subjective (3-point Likert scale) and objective image qualities were compared using Mann-Whitney U-test and paired t-test, respectively. Interobserver agreement, LGE detection rate, and level of certainty were compared using Cohen's kappa, Wilcoxon-test, and Mann-Whitney U-test, respectively. Results are reported as mean +/- SD or mean [95% confidence interval]. RESULTS: Overall, image quality was rated similar between TRAMINER and SIR; however, TRAMINER performed better on a visual assessment of the ability to differentiate LGE from blood (Likert scale: 3.0 [3.0-3.0] vs. 2.0 [1.7-2.2], P < 0.0001). TRAMINER provided significantly higher signal intensity range (69.8 +/- 10.2 vs. 9.6 +/- 7.6, P < 0.0001) and a 4-fold higher signal intensity ratio (4.2 +/- 1.9 vs. 1.1 +/- 0.1, P < 0.0001) between LGE and blood signals. TRAMINER detected more patients (19/40 vs. 17/40) and segments (91/649 vs. 79/649) with LGE with higher level of certainty (2.9 [2.8-3.0] vs. 2.7 [2.5-2.8], P = 0.0185). Interobserver agreement was good to excellent for LGE detection. CONCLUSION: TRAMINER provides better contrast between LGE and blood and consequently may have increased ability to discriminate thin subendocardial and papillary muscle enhancement from the blood signal, which can have an indistinct appearance using SIR. LEVEL OF EVIDENCE: 2 J. MAGN. RESON. IMAGING 2017;45:1429-1437. CI - (c) 2016 International Society for Magnetic Resonance in Medicine. FAU - Muscogiuri, Giuseppe AU - Muscogiuri G AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. AD - Department of Imaging, Bambino Gesu Children's Hospital IRCCS, Rome, Italy. FAU - Rehwald, Wolfgang G AU - Rehwald WG AD - Siemens Medical Solutions, Chicago, Illinois, USA. AD - Cardiovascular MR Center, Duke University Medical Center, Durham, North Carolina, USA. FAU - Schoepf, U Joseph AU - Schoepf UJ AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. FAU - Suranyi, Pal AU - Suranyi P AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. FAU - Litwin, Sheldon E AU - Litwin SE AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. AD - Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. FAU - De Cecco, Carlo N AU - De Cecco CN AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. FAU - Wichmann, Julian L AU - Wichmann JL AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. AD - Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany. FAU - Mangold, Stefanie AU - Mangold S AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. AD - Department of Diagnostic and Interventional Radiology, Eberhard-Karls University Tuebingen, Tuebingen, Germany. FAU - Caruso, Damiano AU - Caruso D AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. AD - Department of Radiological, Oncological and Pathological Sciences, University of Rome "Sapienza", Rome, Italy. FAU - Fuller, Stephen R AU - Fuller SR AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. FAU - Bayer Nd, Richard R AU - Bayer Nd RR AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. AD - Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. FAU - Varga-Szemes, Akos AU - Varga-Szemes A AUID- ORCID: 0000-0002-2781-7462 AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA. LA - eng PT - Journal Article DEP - 20160930 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Aged MH - Contrast Media MH - Electrocardiography MH - Female MH - Gadolinium/*chemistry MH - Humans MH - Image Processing, Computer-Assisted MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Myocardial Infarction/*diagnostic imaging MH - Myocardium/*pathology MH - Observer Variation MH - Prospective Studies MH - Reproducibility of Results OTO - NOTNLM OT - black blood OT - bright blood OT - inversion recovery OT - late gadolinium enhancement OT - myocardial infarction EDAT- 2016/10/01 06:00 MHDA- 2017/10/24 06:00 CRDT- 2016/10/01 06:00 PHST- 2016/07/13 00:00 [received] PHST- 2016/09/14 00:00 [accepted] PHST- 2016/10/01 06:00 [pubmed] PHST- 2017/10/24 06:00 [medline] PHST- 2016/10/01 06:00 [entrez] AID - 10.1002/jmri.25498 [doi] PST - ppublish SO - J Magn Reson Imaging. 2017 May;45(5):1429-1437. doi: 10.1002/jmri.25498. Epub 2016 Sep 30.