PMID- 27690565
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 41
IP  - 10
DP  - 2016 Oct
TI  - Proton-pump inhibitor therapy and vitamin B(12) status in an inpatient hospital 
      setting.
PG  - 1071-1076
LID - 10.1139/apnm-2016-0020 [doi]
AB  - The risk for impaired vitamin B(12) status increases with age, as does the use of 
      proton pump inhibitors (PPI). Long-term use of PPIs is associated with several 
      nutritional deficiencies including B(12). Currently, there are no recommendations 
      for B(12) screening among patients taking PPIs. Data were abstracted on B(12) 
      concentrations, B(12)-containing supplement use, medications, and select 
      hematological values from a retrospective chart review of 658 adults, 391 with 
      serum B(12) concentrations, admitted to 6 different medical units at 2 regional 
      hospitals in Southwestern Ontario between 2010 and 2012. We found no difference 
      between PPI users and nonusers and serum B(12) concentrations (404 +/- 224 vs 369 +/- 
      213 pmol/L; P = 0.0690). This may be due to use of B(12) containing multivitamins 
      in 41% of PPI users. Regression modelling found that aging increases the odds of 
      having an impaired B(12) status (<220 pmol/L) by 1.4 times and those using B(12) 
      supplements are almost 4 times more likely to have an impaired status. Mean 
      corpuscular volume was not related to B(12) status. In this population, older PPI 
      users are more likely to be using multivitamins, which may delay nutritional 
      deficiencies. However, the lower B(12) concentrations of PPI users taking only 
      B(12) supplements is a concern and requires further research. Finally, physicians 
      need to be aware that mean corpuscular volume is no longer recommended as an 
      effective biomarker for B(12) screening and updated screening protocols need to 
      be used to reduce the possibility of adverse neurological effects from impaired 
      B(12) status.
FAU - Hartman, Brenda
AU  - Hartman B
AD  - a Department of Nutritional Sciences, FitzGerald Building, University of Toronto, 
      150 College St, Toronto, ON M5S 3E2.
AD  - b The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8.
FAU - Donnelly-VanderLoo, Mary
AU  - Donnelly-VanderLoo M
AD  - c Brescia University College, 1285 Western Rd, London, ON N6G 1H2.
AD  - d London Health Sciences Centre, 800 Commissioners Rd E, London, ON N6A 5W9.
FAU - Watson, Tiffany
AU  - Watson T
AD  - c Brescia University College, 1285 Western Rd, London, ON N6G 1H2.
FAU - O'Connor, Colleen
AU  - O'Connor C
AD  - c Brescia University College, 1285 Western Rd, London, ON N6G 1H2.
FAU - Madill, Janet
AU  - Madill J
AD  - c Brescia University College, 1285 Western Rd, London, ON N6G 1H2.
LA  - eng
PT  - Journal Article
DEP - 20160623
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
OTO - NOTNLM
OT  - B12
OT  - inhibiteur de la pompe a protons (<< IPP >>)
OT  - mean corpuscular volume (MCV)
OT  - nutrition
OT  - proton pump inhibitor (PPI)
OT  - supplements
OT  - supplements
OT  - volume globulaire moyen (<< MCV >>)
EDAT- 2016/10/04 06:00
MHDA- 2016/10/04 06:01
CRDT- 2016/10/04 06:00
PHST- 2016/10/04 06:00 [pubmed]
PHST- 2016/10/04 06:01 [medline]
PHST- 2016/10/04 06:00 [entrez]
AID - 10.1139/apnm-2016-0020 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2016 Oct;41(10):1071-1076. doi: 10.1139/apnm-2016-0020. 
      Epub 2016 Jun 23.