PMID- 27692590
OWN - NLM
STAT- MEDLINE
DCOM- 20170524
LR  - 20180504
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 127
IP  - 11
DP  - 2016 Nov
TI  - Regional and network relationship in the intracranial EEG second spectrum.
PG  - 3485-3491
LID - S1388-2457(16)30511-9 [pii]
LID - 10.1016/j.clinph.2016.09.003 [doi]
AB  - OBJECTIVE: We examined low-frequency amplitude modulations of band power 
      time-series, i.e. the second spectrum, of the intracranial EEG (icEEG) for 
      evidence of support for spatial relationships between different parts of the 
      brain and within the default mode network (DMN). METHODS: We estimated 
      magnitude-squared coherence (MSC) of the running power in the delta, theta, 
      alpha, beta, and gamma frequency bands for one-hour background icEEG epochs 
      recorded from 9 patients. We isolated two test areas within the DMN and one 
      control area outside it. We tested if the relationship between DMN areas was 
      stronger than the relationship between each of these areas and the control 
      location, and between all intrahemispheric contact pairs with similar 
      intercontact distance. RESULTS: We observed very low values of second spectrum 
      relationship between different parts of the brain, except at very short 
      distances. These relationships are strongest in the delta band and decrease with 
      increasing frequency, with gamma band relationships being the weakest. Our 
      DMN-specific analysis showed no enhanced connectivity in the second spectrum in 
      DMN locations in any frequency band. CONCLUSIONS: Though we observed 
      significantly nonzero relationships in lower frequency bands, second spectrum 
      relationships are consistently very low across the entire brain in every 
      frequency band. SIGNIFICANCE: This study suggests a lack of support for the DMN 
      in the icEEG second spectrum.
CI  - Copyright (c) 2016 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Joshi, Rasesh B
AU  - Joshi RB
AD  - Department of Neurology, Yale University, New Haven, CT 06520, USA.
FAU - Gaspard, Nicolas
AU  - Gaspard N
AD  - Department of Neurology, Yale University, New Haven, CT 06520, USA.
FAU - Goncharova, Irina I
AU  - Goncharova II
AD  - Department of Neurology, Yale University, New Haven, CT 06520, USA.
FAU - Duckrow, Robert B
AU  - Duckrow RB
AD  - Department of Neurology, Yale University, New Haven, CT 06520, USA.
FAU - Duncan, Dominique
AU  - Duncan D
AD  - Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, 
      University of Southern California, Los Angeles, CA 90032, USA.
FAU - Gerrard, Jason L
AU  - Gerrard JL
AD  - Department of Neurosurgery, Yale University, Yale University School of Medicine, 
      New Haven, CT 06520, USA.
FAU - Spencer, Dennis D
AU  - Spencer DD
AD  - Department of Neurosurgery, Yale University, Yale University School of Medicine, 
      New Haven, CT 06520, USA.
FAU - Hirsch, Lawrence J
AU  - Hirsch LJ
AD  - Department of Neurology, Yale University, New Haven, CT 06520, USA.
FAU - Zaveri, Hitten P
AU  - Zaveri HP
AD  - Department of Neurology, Yale University, New Haven, CT 06520, USA. Electronic 
      address: hitten.zaveri@yale.edu.
LA  - eng
PT  - Journal Article
DEP - 20160910
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping/*methods
MH  - Child
MH  - Electroencephalography/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Net/*physiology
MH  - Random Allocation
MH  - Young Adult
OTO - NOTNLM
OT  - Coherence
OT  - Epilepsy
OT  - Intracranial EEG
OT  - Resting state networks
EDAT- 2016/10/27 06:00
MHDA- 2017/05/26 06:00
CRDT- 2016/10/04 06:00
PHST- 2015/05/27 00:00 [received]
PHST- 2016/08/03 00:00 [revised]
PHST- 2016/09/04 00:00 [accepted]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2017/05/26 06:00 [medline]
PHST- 2016/10/04 06:00 [entrez]
AID - S1388-2457(16)30511-9 [pii]
AID - 10.1016/j.clinph.2016.09.003 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2016 Nov;127(11):3485-3491. doi: 10.1016/j.clinph.2016.09.003. 
      Epub 2016 Sep 10.