PMID- 27693988
OWN - NLM
STAT- MEDLINE
DCOM- 20170213
LR  - 20191023
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 47
DP  - 2016 Oct
TI  - Gestational and lactational exposure to low-dose bisphenol A increases Th17 cells 
      in mice offspring.
PG  - 149-158
LID - S1382-6689(16)30247-2 [pii]
LID - 10.1016/j.etap.2016.09.017 [doi]
AB  - Increasing evidence demonstrates that perinatal exposure to Bisphenol A (BPA) can 
      cause immune disorders throughout the life span. However, the biological basis 
      for these immune disorders is poorly understood and the effects of exposure to 
      BPA on Th17 development are unknown. The present study sought to characterize 
      alterations of Th17 cells in childhood and adulthood following gestational and 
      lactational exposure to environmentally relevant low-dose of BPA and the 
      underlying mechanisms. Pregnant dams were exposed to BPA (10, 100 or 1000nM) via 
      drinking water from gestational day (GD) 0 to postnatal day (PND) 21. At PNDs 21 
      and 42, offspring mice were anesthetized, blood was obtained for cytokine assay 
      and spleens were collected for Th17 cell frequency and RORgammat mRNA expression 
      analysis. Perinatal exposure to low-dose BPA resulted in a dose-dependent and 
      gender-specific persistent rise in Th17 cells accompanied by an increase of RORgammat 
      mRNA expression in the offsprings. The contents of major Th17 cell-derived 
      cytokines (IL-17 and IL-21) and those essential for Th17 cell differentiation 
      (IL-6 and IL-23) were also increased compared to those in controls. These changes 
      were more pronounced in female than in male offsprings. However, perinatal 
      exposure to low-dose BPA had little effect on serum TGF-beta, another key regulator 
      for Th17 cell development. Our results suggest that gestational and lactational 
      exposure to a low-dose of BPA can affect Th17 cell development via an action on 
      its transcription factor and the regulatory cytokines. These findings provide 
      novel insight into sustained immune disorders by BPA exposure during development.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Luo, Shimeng
AU  - Luo S
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei 230032, Anhui, PR China.
FAU - Li, Yun
AU  - Li Y
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei 230032, Anhui, PR China.
FAU - Li, Yingpei
AU  - Li Y
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei 230032, Anhui, PR China.
FAU - Zhu, Qixing
AU  - Zhu Q
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei 230032, Anhui, PR China; Department of Occupational Health and 
      Environmental Health, School of Public Health, Anhui Medical University, Hefei 
      230032, Anhui, PR China; Institute of Dermatology, Anhui Medical University, 
      Hefei 230032, Anhui, PR China.
FAU - Jiang, Jianhua
AU  - Jiang J
AD  - Department of Clinical Nutriology, The First Affiliated Hospital, Anhui Medical 
      University, Hefei 230022, Anhui, PR China.
FAU - Wu, Changhao
AU  - Wu C
AD  - Department of Biochemistry and Physiology, Faculty of Heath & Medical Sciences, 
      University of Surrey, Surrey, Guildford, UK.
FAU - Shen, Tong
AU  - Shen T
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei 230032, Anhui, PR China; Department of Occupational Health and 
      Environmental Health, School of Public Health, Anhui Medical University, Hefei 
      230032, Anhui, PR China; Institute of Dermatology, Anhui Medical University, 
      Hefei 230032, Anhui, PR China. Electronic address: ahmusht@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160926
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-23)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - 0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
RN  - 0 (Phenols)
RN  - MKM3CA6LT1 (interleukin-21)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/administration & dosage/*toxicity
MH  - Birth Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Interleukin-17/metabolism
MH  - Interleukin-23/metabolism
MH  - Interleukin-6/metabolism
MH  - Interleukins/metabolism
MH  - Lactation
MH  - Male
MH  - Maternal Exposure/adverse effects
MH  - Mice, Inbred ICR
MH  - Nuclear Receptor Subfamily 1, Group F, Member 3/genetics
MH  - Phenols/administration & dosage/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Spleen/drug effects/pathology
MH  - Th17 Cells/*drug effects/metabolism
MH  - Weaning
OTO - NOTNLM
OT  - Bisphenol A
OT  - Cytokine
OT  - Maternal exposure
OT  - RORgammat
OT  - Th17 cells
EDAT- 2016/10/31 06:00
MHDA- 2017/02/14 06:00
CRDT- 2016/10/04 06:00
PHST- 2016/07/17 00:00 [received]
PHST- 2016/09/22 00:00 [revised]
PHST- 2016/09/24 00:00 [accepted]
PHST- 2016/10/31 06:00 [pubmed]
PHST- 2017/02/14 06:00 [medline]
PHST- 2016/10/04 06:00 [entrez]
AID - S1382-6689(16)30247-2 [pii]
AID - 10.1016/j.etap.2016.09.017 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2016 Oct;47:149-158. doi: 10.1016/j.etap.2016.09.017. 
      Epub 2016 Sep 26.