PMID- 27694490
OWN - NLM
STAT- MEDLINE
DCOM- 20171225
LR  - 20190202
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 6
IP  - 9
DP  - 2016 Sep 30
TI  - Effect of vitreomacular adhesion and vitreous gel on age-related reduction of 
      macular thickness: a retrospective observational study.
PG  - e012972
LID - 10.1136/bmjopen-2016-012972 [doi]
LID - e012972
AB  - OBJECTIVE: To investigate the effects of vitreomacular adhesion (VMA), 
      vitreomacular separation (VMS) and absence of vitreous gel due to vitrectomy on 
      macular thickness measured in the spectral domain optical coherence tomographic 
      (SD-OCT) images. DESIGN: A longitudinal, retrospective, observational study. 
      SETTING: Secondary multicentre study. PARTICIPANTS: 218 eyes of 218 healthy 
      patients and 119 vitrectomised eyes of 119 patients were studied. The healthy 
      individuals were classified into a VMA group (54 eyes) and a VMS group (164 
      eyes), while the vitrectomised patients were classified into an internal limiting 
      membrane (ILM)-on group (26 eyes) and an ILM-off group (93 eyes). In all 
      participants, 2 Cirrus HD-OCT recordings were made with an average interval of 
      36 months (range 24-60 months). PRIMARY AND SECONDARY OUTCOME MEASURES: The 
      primary outcome measure was the rate of change in macular thickness in the 
      central sector. The secondary outcomes were the rates of change in macular 
      thickness in the inner 4 sectors. RESULTS: The annual rate of change in the 
      macular thickness of the central sector was 0.76+/-1.8 microm/year in the VMA group, 
      -0.58+/-2.3 microm/year in the VMS group, -1.57+/-1.9 microm/year in the ILM-on group and 
      -0.86+/-3.1 microm/year in the ILM-off group. There was a significant difference 
      between the rate of the central sector thickness change in the VMA and VMS groups 
      (p=0.0001). The presence of VMA was a significant factor associated with an 
      increase in the central sector thickness (p=0.0055). When the healthy and ILM-on 
      groups were compared, the rate of decrease in the central sector thickness was 
      faster in the ILM-on group (p=0.0043). Multiple regression analyses showed that 
      not peeling the ILM during the vitrectomy was a significant factor associated 
      with a decrease in the central sector thickness (p=0.044). CONCLUSIONS: The 
      presence of a VMA and a vitreous gel may help restrain the macular thickness 
      reduction.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Kumagai, Kazuyuki
AU  - Kumagai K
AD  - Kami-iida Daiichi General Hospital, Aichi, Japan.
FAU - Hangai, Masanori
AU  - Hangai M
AD  - Department of Ophthalmology, Faculty of Medicine, Saitama Medical University, 
      Iruma, Japan.
FAU - Furukawa, Mariko
AU  - Furukawa M
AD  - Kami-iida Daiichi General Hospital, Aichi, Japan.
FAU - Suetsugu, Tetsuyuki
AU  - Suetsugu T
AUID- ORCID: 0000-0003-3682-3167
AD  - Kami-iida Daiichi General Hospital, Aichi, Japan.
FAU - Ogino, Nobuchika
AU  - Ogino N
AD  - Shinjo Ophthalmologic Institute, Miyazaki, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20160930
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Japan
MH  - Longitudinal Studies
MH  - Macula Lutea/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Regression Analysis
MH  - Retina/*diagnostic imaging
MH  - Retrospective Studies
MH  - Tissue Adhesions/*diagnostic imaging
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
MH  - *Vitrectomy
PMC - PMC5051463
EDAT- 2016/10/04 06:00
MHDA- 2017/12/26 06:00
PMCR- 2016/09/30
CRDT- 2016/10/04 06:00
PHST- 2016/10/04 06:00 [entrez]
PHST- 2016/10/04 06:00 [pubmed]
PHST- 2017/12/26 06:00 [medline]
PHST- 2016/09/30 00:00 [pmc-release]
AID - bmjopen-2016-012972 [pii]
AID - 10.1136/bmjopen-2016-012972 [doi]
PST - epublish
SO  - BMJ Open. 2016 Sep 30;6(9):e012972. doi: 10.1136/bmjopen-2016-012972.