PMID- 27695917
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20221207
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 69
IP  - 1
DP  - 2017 Jan
TI  - Elucidating the origin of HLA-B*73 allelic lineage: Did modern humans benefit by 
      archaic introgression?
PG  - 63-67
LID - 10.1007/s00251-016-0952-8 [doi]
AB  - A previous study reported that some of the human leukocyte antigen (HLA) alleles 
      and haplotypes in present-day humans were acquired by admixture with archaic 
      humans; specifically, an exceptionally diverged HLA-B*73 allele was proposed to 
      be transmitted from Denisovans, although the DNA sequence of HLA-B*73 has not 
      been detected in the Denisovan genome. Here, we argue against the hypothesis that 
      HLA-B*73 introgressed from Denisovans into early modern humans. A phylogenetic 
      analysis revealed that HLA-B*73:01 formed a monophyletic group with a chimpanzee 
      MHC-B allele, strongly suggesting that the HLA-B*73 allelic lineage has been 
      maintained in humans as well as in chimpanzees since the divergence of humans and 
      chimpanzees. The global distribution of HLA-B*73 allele showed that the 
      population frequency of HLA-B*73 in west Asia (0.24 %)-a possible site of 
      admixture with Denisovans-is lower than that in Europe (0.72 %) and in south Asia 
      (0.69 %). Furthermore, HLA-B*73 is not observed in Melanesia even though the 
      Melanesian genome contains the highest proportion of Denisovan ancestry in 
      present-day human populations. Single nucleotide polymorphisms in 
      HLA-A*11-HLA-C*12:02 or HLA-A*11-C*15 haplotypes, one of which was assumed to be 
      transmitted together with HLA-B*73 from Denisovans by the study of Abi-Rached and 
      colleagues, were not differentiated from those in other HLA-A-C haplotypes in 
      modern humans. These results do not support the introgression hypothesis. Thus, 
      we conclude that it is highly likely that HLA-B*73 allelic lineage has been 
      maintained in the direct ancestors of modern humans.
FAU - Yasukochi, Yoshiki
AU  - Yasukochi Y
AD  - Department of Human Functional Genomics, Life Science Research Center, Mie 
      University, 1577 Kurima-machiya, Tsu, Mie, 514-8507, Japan. 
      hyasukou@proof.ocn.ne.jp.
FAU - Ohashi, Jun
AU  - Ohashi J
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160930
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B73 antigen)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Asian People/genetics
MH  - Black People/genetics
MH  - Europe
MH  - *Evolution, Molecular
MH  - *Genome, Human
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Hominidae/classification/*genetics
MH  - Humans
MH  - Neanderthals/genetics
MH  - Pan troglodytes/genetics
MH  - Phylogeny
PMC - PMC5203853
OTO - NOTNLM
OT  - Allelic divergence
OT  - Denisovan
OT  - HLA
OT  - HLA-B*73
OT  - Introgression
OT  - Neanderthal
EDAT- 2016/10/04 06:00
MHDA- 2017/05/16 06:00
PMCR- 2016/09/30
CRDT- 2016/10/04 06:00
PHST- 2016/07/14 00:00 [received]
PHST- 2016/09/16 00:00 [accepted]
PHST- 2016/10/04 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/10/04 06:00 [entrez]
PHST- 2016/09/30 00:00 [pmc-release]
AID - 10.1007/s00251-016-0952-8 [pii]
AID - 952 [pii]
AID - 10.1007/s00251-016-0952-8 [doi]
PST - ppublish
SO  - Immunogenetics. 2017 Jan;69(1):63-67. doi: 10.1007/s00251-016-0952-8. Epub 2016 
      Sep 30.