PMID- 27696366
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20220331
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 134
IP  - 5
DP  - 2016 Nov
TI  - Five-year study of quality of life in myotonic dystrophy.
PG  - 346-351
LID - 10.1111/ane.12549 [doi]
AB  - Background - Myotonic dystrophy type 1 (DM1) is the most common muscular 
      dystrophy in adults. There is a complete lack of studies that assessed quality of 
      life (QoL) trajectory during time in DM1 cohorts. Aim - To analyze changes of QoL 
      in patients with DM1 during a 5-year follow-up period and to assess 
      responsiveness of the SF-36 questionnaire. Patients and Method - At the baseline, 
      this study comprised 84 DM1 patients, of whom 62 were retested after the mean 
      period of 64.2 +/- 3.9 months. Severity of muscular weakness was assessed using the 
      Muscular Impairment Rating Scale (MIRS). Patients completed Serbian version of 
      the SF-36 questionnaire as a measure of health-related QoL. Results - After 
      5 years, MIRS score of our DM1 patients showed significant progression of 0.5 
      grade (P < 0.01). All mental subdomains, role physical, and total SF-36 scores 
      significantly improved after 5 years (P < 0.01). Unexpectedly, worsening of 
      muscular weakness from mild to severe was in association with improvement of QoL. 
      Conclusion - QoL improved in our cohort of DM1 patients during a 5-year period 
      despite the progression of the disease. SF-36 should be used with caution as a 
      patient-reported outcome measure in DM1 clinical trials.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Peric, S
AU  - Peric S
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia. stojanperic@gmail.com.
FAU - Vujnic, M
AU  - Vujnic M
AD  - Department of Pathophysiology, Faculty of Medicine, University of Banja Luka, 
      Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
FAU - Dobricic, V
AU  - Dobricic V
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Marjanovic, A
AU  - Marjanovic A
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Basta, I
AU  - Basta I
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Novakovic, I
AU  - Novakovic I
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
AD  - Institute of Human Genetics, School of Medicine, University of Belgrade, 
      Belgrade, Serbia.
FAU - Lavrnic, D
AU  - Lavrnic D
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Rakocevic-Stojanovic, V
AU  - Rakocevic-Stojanovic V
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20151221
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
SB  - IM
MH  - Adult
MH  - *Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myotonic Dystrophy/*physiopathology
MH  - *Quality of Life
OTO - NOTNLM
OT  - SF-36
OT  - follow-up
OT  - myotonic dystrophy type 1
OT  - quality of life
OT  - responsiveness
EDAT- 2016/10/04 06:00
MHDA- 2017/01/18 06:00
CRDT- 2016/10/04 06:00
PHST- 2015/11/24 00:00 [accepted]
PHST- 2016/10/04 06:00 [entrez]
PHST- 2016/10/04 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
AID - 10.1111/ane.12549 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2016 Nov;134(5):346-351. doi: 10.1111/ane.12549. Epub 2015 Dec 
      21.