PMID- 27697025
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20220129
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 22
IP  - 45
DP  - 2016
TI  - Immunological Mechanisms of Drug Hypersensitivity.
PG  - 6734-6747
LID - 10.2174/1381612822666161003115103 [doi]
AB  - Drug hypersensitivity reactions (DHRs) are adverse drug reactions that may be 
      divided into several categories; namely pharmacologic intolerance, idiosyncratic 
      reactions, pseudo-allergic reactions and allergic reactions. Drug allergic 
      reactions are those DHRs that are mediated by either antibodies or drug-specific 
      T cells. They vary in terms of severity, time-to-onset of clinical manifestations 
      and target organ. Skin is most commonly implicated in drug hypersensitivity 
      reactions; however, it is now apparent that reactions targeting internal organs 
      fall under the definition of drug hypersensitivity. Multiple hypotheses have been 
      proposed to explain the diverse immune mechanisms involved and the heterogeneous 
      clinical presentation. The discovery of human leukocyte antigen (HLA) risk 
      alleles for some DHRs has provided insights in the pathogenesis of these 
      reactions. In this review we summarize immune cells involved in DHRs, discuss the 
      possible immunological mechanisms of DHRs, with an emphasis on the IgE-mediated 
      immediate reactions and T cell-dependent delayed type reactions.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Meng, Xiaoli
AU  - Meng X
FAU - Ariza, Adriana
AU  - Ariza A
FAU - Waddington, James
AU  - Waddington J
FAU - Park, Kevin
AU  - Park K
FAU - Naisbitt, Dean
AU  - Naisbitt D
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom.
LA  - eng
GR  - MR/L006758/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*adverse effects/*immunology
MH  - Drug Hypersensitivity/*immunology
MH  - Humans
MH  - Hypersensitivity, Delayed/*immunology
MH  - T-Lymphocytes/drug effects/*immunology
OTO - NOTNLM
OT  - Drug hypersensitivity
OT  - IgE.
OT  - T-cells
EDAT- 2016/10/05 06:00
MHDA- 2017/12/23 06:00
CRDT- 2016/10/05 06:00
PHST- 2016/07/09 00:00 [received]
PHST- 2016/09/28 00:00 [accepted]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
PHST- 2016/10/05 06:00 [entrez]
AID - CPD-EPUB-78713 [pii]
AID - 10.2174/1381612822666161003115103 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2016;22(45):6734-6747. doi: 10.2174/1381612822666161003115103.