PMID- 27697521
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20170821
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 634
DP  - 2016 Nov 10
TI  - Activation of arginine vasopressin receptor 1a facilitates the induction of 
      long-term potentiation in the accessory olfactory bulb of male mice.
PG  - 107-113
LID - S0304-3940(16)30740-6 [pii]
LID - 10.1016/j.neulet.2016.09.056 [doi]
AB  - Olfaction plays an important role in social recognition in most mammals. Central 
      arginine vasopressin (AVP) plays a role in this olfaction-based recognition. The 
      high level of expression of AVP receptors in the accessory olfactory bulb (AOB) 
      at the first relay of the vomeronasal system highlights the importance of AVP 
      signaling at this stage. We therefore analyzed the effects of AVP on the synaptic 
      plasticity of glutamatergic transmission from mitral cells to granule cells in 
      AOB slices from male mice. To monitor the strength of the glutamatergic 
      transmission, we measured the maximal initial slope of the lateral olfactory 
      tract-evoked field potential, which represents the granule cell response to 
      mitral cell activation. AVP paired with 100-Hz stimulation that only produced 
      short-term potentiation enhanced the induction of long-term potentiation (LTP) in 
      a dose-dependent manner. AVP-paired LTP was blocked by the selective AVP receptor 
      1a (AVPR1a) antagonist, d(CH(2))(5)[Tyr(Me)(2)]AVP (Manning compound), but not by 
      the AVPR1b antagonist SSR149415, and it was mimicked by the selective AVPR1a 
      agonist [Phe(2), Ile(3), Orn(8)]-vasopressin. We further examined the effect of 
      AVP on the reciprocal transmission between mitral and granule cells by 
      stimulating a mitral cell and recording the evoked inhibitory postsynaptic 
      currents (IPSCs) from the same cell using conventional whole-cell patch-clamp 
      techniques. AVP reduced the reciprocal IPSCs triggered by endogenous glutamate 
      release from the excited mitral cell. These results suggest that AVP promotes the 
      induction of LTP at the mitral-to-granule cell synapse via the activation of 
      AVPR1a through an as-yet-to-be-determined mechanism in the AOB of male mice.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Namba, Toshiharu
AU  - Namba T
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Taniguchi, Mutsuo
AU  - Taniguchi M
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Murata, Yoshihiro
AU  - Murata Y
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Tong, Jia
AU  - Tong J
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan; Department of Occupational Health, Kochi Medical School, Kochi 
      University, Nankoku, Kochi 783-8505, Japan.
FAU - Wang, Yujie
AU  - Wang Y
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Okutani, Fumino
AU  - Okutani F
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan; Department of Occupational Health, Kochi Medical School, Kochi 
      University, Nankoku, Kochi 783-8505, Japan.
FAU - Yamaguchi, Masahiro
AU  - Yamaguchi M
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan.
FAU - Kaba, Hideto
AU  - Kaba H
AD  - Department of Physiology, Kochi Medical School, Kochi University, Nankoku, Kochi 
      783-8505, Japan. Electronic address: kabah@kochi-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20160930
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 
      (1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide)
RN  - 0 (AVPR1a receptor, mouse)
RN  - 0 (Antidiuretic Hormone Receptor Antagonists)
RN  - 0 (Indoles)
RN  - 0 (Pyrrolidines)
RN  - 0 (Receptors, Vasopressin)
RN  - 0 (vasopressin, Phe(2)-Ile(3)-Hgn(4)-Orn(iPr)(8)-)
RN  - 11000-17-2 (Vasopressins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Antidiuretic Hormone Receptor Antagonists/pharmacology
MH  - Arginine Vasopressin/metabolism/pharmacology
MH  - Electric Stimulation
MH  - Glutamic Acid/physiology
MH  - Indoles/pharmacology
MH  - Inhibitory Postsynaptic Potentials
MH  - *Long-Term Potentiation
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Neurons/physiology
MH  - Olfactory Bulb/cytology/drug effects/*physiology
MH  - Pyrrolidines/pharmacology
MH  - Receptors, Vasopressin/*agonists
MH  - Synaptic Transmission
MH  - Vasopressins/pharmacology
OTO - NOTNLM
OT  - Accessory olfactory bulb
OT  - Dendrodendritic inhibition
OT  - Long-term potentiation
OT  - Reciprocal synapse
OT  - Vasopressin
OT  - Vasopressin receptor
EDAT- 2016/10/26 06:00
MHDA- 2017/08/22 06:00
CRDT- 2016/11/07 06:00
PHST- 2016/07/30 00:00 [received]
PHST- 2016/09/28 00:00 [revised]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2016/11/07 06:00 [entrez]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
AID - S0304-3940(16)30740-6 [pii]
AID - 10.1016/j.neulet.2016.09.056 [doi]
PST - ppublish
SO  - Neurosci Lett. 2016 Nov 10;634:107-113. doi: 10.1016/j.neulet.2016.09.056. Epub 
      2016 Sep 30.