PMID- 27697531
OWN - NLM
STAT- MEDLINE
DCOM- 20170523
LR  - 20201214
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 479
IP  - 4
DP  - 2016 Oct 28
TI  - PMEPA1, a TGF-beta- and hypoxia-inducible gene that participates in hypoxic gene 
      expression networks in solid tumors.
PG  - 615-621
LID - S0006-291X(16)31651-5 [pii]
LID - 10.1016/j.bbrc.2016.09.166 [doi]
AB  - Prostate transmembrane protein, androgen induced 1 (PMEPA1) is highly expressed 
      in various solid tumors and is known to play important roles in the transforming 
      growth factor-beta (TGF-beta) signaling pathway. Here, we demonstrate a novel 
      relationship between PMEPA1 and hypoxia, a common microenvironmental stress 
      condition in solid tumors. We showed that induction of PMEPA1 expression occurred 
      during hypoxia in a manner dependent on both TGF-beta signaling and 
      hypoxia-inducible factor-1 (HIF-1) pathways. Furthermore, overexpression and 
      knockdown experiments revealed that PMEPA1 enhanced HIF-1 transcription activity. 
      Bioinformatics analyses of PMEPA1-correlated genes using a gene expression 
      database in clinical settings showed significant enrichment of gene sets defined 
      by TGF-beta and hypoxia and these two signaling pathways-related angiogenesis and 
      epithelial-mesenchymal transition in many types of solid tumors. Collectively, 
      our findings indicated that PMEPA1 participates in TGF-beta- and hypoxia-regulated 
      gene expression networks in solid tumors and thereby may contribute to tumor 
      progression.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Koido, Masaru
AU  - Koido M
AD  - Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 
      Ariake, Koto-ku, Tokyo 135-8550, Japan; Department of Medical Genome Sciences, 
      Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 
      Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
FAU - Sakurai, Junko
AU  - Sakurai J
AD  - Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 
      Ariake, Koto-ku, Tokyo 135-8550, Japan.
FAU - Tsukahara, Satomi
AU  - Tsukahara S
AD  - Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 
      Ariake, Koto-ku, Tokyo 135-8550, Japan.
FAU - Tani, Yuri
AU  - Tani Y
AD  - Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 
      Ariake, Koto-ku, Tokyo 135-8550, Japan.
FAU - Tomida, Akihiro
AU  - Tomida A
AD  - Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 
      Ariake, Koto-ku, Tokyo 135-8550, Japan; Department of Medical Genome Sciences, 
      Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 
      Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address: 
      akihiro.tomida@jfcr.or.jp.
LA  - eng
PT  - Journal Article
DEP - 20161001
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (HIGD1A protein, human)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PMEPA1 protein, human)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Cell Line, Tumor
MH  - *Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Membrane Proteins/genetics/*metabolism
MH  - Mitochondrial Proteins
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Neoplasms/*genetics/*pathology
MH  - Transcription, Genetic
MH  - Transforming Growth Factor beta/genetics/*metabolism
MH  - Tumor Hypoxia/*genetics
OTO - NOTNLM
OT  - Hypoxia
OT  - PMEPA1
OT  - TGF-beta
EDAT- 2016/10/05 06:00
MHDA- 2017/05/24 06:00
CRDT- 2016/10/05 06:00
PHST- 2016/09/26 00:00 [received]
PHST- 2016/09/30 00:00 [accepted]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2017/05/24 06:00 [medline]
PHST- 2016/10/05 06:00 [entrez]
AID - S0006-291X(16)31651-5 [pii]
AID - 10.1016/j.bbrc.2016.09.166 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2016 Oct 28;479(4):615-621. doi: 
      10.1016/j.bbrc.2016.09.166. Epub 2016 Oct 1.