PMID- 27697546
OWN - NLM
STAT- MEDLINE
DCOM- 20170721
LR  - 20240325
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Print)
IS  - 1568-1637 (Linking)
VI  - 34
DP  - 2017 Mar
TI  - Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative 
      diseases: An aging effect.
PG  - 77-87
LID - S1568-1637(16)30117-9 [pii]
LID - 10.1016/j.arr.2016.09.006 [doi]
AB  - Current understanding on the mechanisms of brain injury and neurodegeneration 
      highlights an appreciation of multicellular interactions within the neurovascular 
      unit (NVU), which include the evolution of blood-brain barrier (BBB) damage, 
      neuronal cell death or degeneration, glial reaction, and immune cell 
      infiltration. Aging is an important factor that influences the integrity of the 
      NVU. The age-related physiological or pathological changes in the cellular 
      components of the NVU have been shown to increase the vulnerability of the NVU to 
      ischemia/reperfusion injury or neurodegeneration, and to result in deteriorated 
      brain damage. This review describes the impacts of aging on each NVU component 
      and discusses the mechanisms by which aging increases NVU sensitivity to stroke 
      and neurodegenerative diseases. Prophylactic or therapeutic perspectives that may 
      delay or diminish aging and thus prevent the incidence of these neurological 
      disorders will also be reviewed.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Cai, Wei
AU  - Cai W
AD  - Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh 
      Health Care System, Pittsburgh, PA 15261, USA; Department of Neurology, The Third 
      Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, 
      China; Pittsburgh Institute of Brain Disorders and Recovery, University of 
      Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
FAU - Zhang, Kai
AU  - Zhang K
AD  - Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh 
      Health Care System, Pittsburgh, PA 15261, USA; Pittsburgh Institute of Brain 
      Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15213, USA.
FAU - Li, Peiying
AU  - Li P
AD  - Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School 
      of Medicine, Shanghai 200127, China; Pittsburgh Institute of Brain Disorders and 
      Recovery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
FAU - Zhu, Ling
AU  - Zhu L
AD  - Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh 
      Health Care System, Pittsburgh, PA 15261, USA; Department of Anesthesiology, 
      Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, 
      China; Pittsburgh Institute of Brain Disorders and Recovery, University of 
      Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
FAU - Xu, Jing
AU  - Xu J
AD  - Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh 
      Health Care System, Pittsburgh, PA 15261, USA; Pittsburgh Institute of Brain 
      Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15213, USA.
FAU - Yang, Boyu
AU  - Yang B
AD  - Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh 
      Health Care System, Pittsburgh, PA 15261, USA; Pittsburgh Institute of Brain 
      Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15213, USA.
FAU - Hu, Xiaoming
AU  - Hu X
AD  - Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh 
      Health Care System, Pittsburgh, PA 15261, USA; Pittsburgh Institute of Brain 
      Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15213, USA.
FAU - Lu, Zhengqi
AU  - Lu Z
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, Guangdong, 510630, China. Electronic address: lzq1828@aliyun.com.
FAU - Chen, Jun
AU  - Chen J
AD  - Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh 
      Health Care System, Pittsburgh, PA 15261, USA; Pittsburgh Institute of Brain 
      Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15213, USA. Electronic address: chenj2@upmc.edu.
LA  - eng
GR  - R01 NS089534/NS/NINDS NIH HHS/United States
GR  - R01 NS095671/NS/NINDS NIH HHS/United States
GR  - I01 BX002495/BX/BLRD VA/United States
GR  - I01 RX000420/RX/RRD VA/United States
GR  - R01 NS036736/NS/NINDS NIH HHS/United States
GR  - R01 NS045048/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20160930
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Aging/*physiology
MH  - Blood-Brain Barrier
MH  - *Brain/blood supply/pathology/physiopathology
MH  - Humans
MH  - *Neurodegenerative Diseases/pathology/physiopathology
MH  - Neurovascular Coupling/*physiology
MH  - *Stroke/pathology/physiopathology
PMC - PMC5384332
MID - NIHMS821838
OTO - NOTNLM
OT  - Aging
OT  - Ischemic stroke
OT  - Neurodegeneration
OT  - Neurovascular unit
OT  - Vulnerability
EDAT- 2016/10/05 06:00
MHDA- 2017/07/22 06:00
PMCR- 2018/03/01
CRDT- 2016/10/05 06:00
PHST- 2016/06/13 00:00 [received]
PHST- 2016/08/15 00:00 [revised]
PHST- 2016/09/26 00:00 [accepted]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2017/07/22 06:00 [medline]
PHST- 2016/10/05 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - S1568-1637(16)30117-9 [pii]
AID - 10.1016/j.arr.2016.09.006 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2017 Mar;34:77-87. doi: 10.1016/j.arr.2016.09.006. Epub 2016 Sep 
      30.