PMID- 27697634
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20181202
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 219
DP  - 2016 Dec
TI  - Accumulation of persistent organic pollutants in consumers of eel from polluted 
      rivers compared to marketable eel.
PG  - 80-88
LID - S0269-7491(16)31191-5 [pii]
LID - 10.1016/j.envpol.2016.09.019 [doi]
AB  - Globally, many river sediments are seriously contaminated with persistent organic 
      pollutants (POPs) known to accumulate in aquatic food. In the Netherlands, 
      toxicological risks of human exposure to dioxins and dioxin-like compounds led to 
      a ban on eel fishing in the Rhine-Meuse delta. The aim of this study is to 
      investigate differences in serum POP levels in consumers of eel from 
      high-polluted areas and consumers of eel from low-polluted areas or aquaculture. 
      In total 80 Dutch men were included, aged 40-70 years, with a habitual eel 
      consumption of at least one portion (150 g) per month. Total levels of dioxins 
      and dioxin-like compounds were measured in serum of all participants with the DR 
      CALUX bioassay, validated with GC-MS. For a subgroup of 38 participants extensive 
      POP measurements were performed. We revealed that consumption of eel from 
      polluted rivers resulted in 2.5 and up to 10 times increased levels of dioxins 
      and polychlorinated biphenyls (PCBs) respectively compared to controls. The 
      highest PCB levels were detected for PCB 153, with a median level of 896 ng/g 
      lipid and a maximum level of 5000 ng/g lipid in the high-exposed group. 
      Furthermore, hydroxylated PCB metabolites (OH-PCBs: sum of 4-OH-CB107, 
      4-OH-CB146, 4'-OH-CB172, and 4-OH-CB187) were 8 times higher in men who consumed 
      eel from polluted areas, and detected at levels (median 4.5 ng/g ww) reported to 
      cause adverse health effects. Also, the majority of the perfluoroalkyl substances 
      (PFASs) were significantly higher in consumers of eel from pullulated areas. In 
      conclusion, this study is the first to reveal that (past) consumption of eel from 
      polluted rivers resulted in high body burdens of dioxins, PCBs, OH-PCBs and 
      PFASs. We confirmed the predictions made in a former risk assessment, and the 
      high levels of dioxins and dioxin-like compounds as well as the OH-PCBs are of 
      health concern.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - van den Dungen, Myrthe W
AU  - van den Dungen MW
AD  - Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, 
      Wageningen, The Netherlands; Marine Animal Ecology Group, Wageningen University, 
      P.O. Box 338, 6700 AH, Wageningen, The Netherlands. Electronic address: 
      myrthevddungen@hotmail.com.
FAU - Kok, Dieuwertje E
AU  - Kok DE
AD  - Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, 
      Wageningen, The Netherlands. Electronic address: Dieuwertje.Kok@wur.nl.
FAU - Polder, Anuschka
AU  - Polder A
AD  - Norwegian University of Life Sciences, Campus Adamstua, P.O. Box 8146 Dep., 
      N-0033, Oslo, Norway; Environmental Sciences and Management, North-West 
      University, PB X6001, Potchefstroom 2520, South Africa. Electronic address: 
      Anuschka.Polder@nmbu.no.
FAU - Hoogenboom, Ron L A P
AU  - Hoogenboom RLAP
AD  - RIKILT Wageningen UR, P.O. Box 230, 6708 WB, Wageningen, The Netherlands. 
      Electronic address: Ron.Hoogenboom@wur.nl.
FAU - van Leeuwen, Stefan P J
AU  - van Leeuwen SPJ
AD  - RIKILT Wageningen UR, P.O. Box 230, 6708 WB, Wageningen, The Netherlands. 
      Electronic address: Stefan.vanLeeuwen@wur.nl.
FAU - Steegenga, Wilma T
AU  - Steegenga WT
AD  - Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, 
      Wageningen, The Netherlands. Electronic address: Wilma.Steegenga@wur.nl.
FAU - Kampman, Ellen
AU  - Kampman E
AD  - Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, 
      Wageningen, The Netherlands. Electronic address: Ellen.Kampman@wur.nl.
FAU - Murk, Albertinka J
AU  - Murk AJ
AD  - Marine Animal Ecology Group, Wageningen University, P.O. Box 338, 6700 AH, 
      Wageningen, The Netherlands. Electronic address: Tinka.Murk@wur.nl.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160930
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Dioxins)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anguilla/*metabolism
MH  - Animals
MH  - Aquaculture
MH  - Biological Assay/methods
MH  - Dioxins/*blood/*toxicity
MH  - Eels/metabolism
MH  - Environmental Monitoring/methods
MH  - Environmental Pollution
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Polychlorinated Biphenyls/*blood/*toxicity
MH  - Rivers/chemistry
MH  - Water Pollutants, Chemical/*blood/*toxicity
OTO - NOTNLM
OT  - Consumer health
OT  - Dioxins
OT  - Hydroxylated PCBs
OT  - PFOS
OT  - Persistent organic pollutants (POPs)
OT  - eel (Anguilla anguilla)
EDAT- 2016/10/05 06:00
MHDA- 2017/02/28 06:00
CRDT- 2016/10/05 06:00
PHST- 2016/04/05 00:00 [received]
PHST- 2016/08/28 00:00 [revised]
PHST- 2016/09/06 00:00 [accepted]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
PHST- 2016/10/05 06:00 [entrez]
AID - S0269-7491(16)31191-5 [pii]
AID - 10.1016/j.envpol.2016.09.019 [doi]
PST - ppublish
SO  - Environ Pollut. 2016 Dec;219:80-88. doi: 10.1016/j.envpol.2016.09.019. Epub 2016 
      Sep 30.