PMID- 27698345
OWN - NLM
STAT- MEDLINE
DCOM- 20180216
LR  - 20231112
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 41
IP  - 1
DP  - 2017 Jan
TI  - Weight losses with low-energy formula diets in obese patients with and without 
      type 2 diabetes: systematic review and meta-analysis.
PG  - 96-101
LID - 10.1038/ijo.2016.175 [doi]
AB  - AIM: To provide a systematic review, of published data, to compare weight losses 
      following very low calorie (<800 kcal per day VLCD) or low-energy liquid-formula 
      (>800 kcal per day LELD) diets, in people with and without type 2 diabetes 
      mellitus (T2DM). METHODS: Systematic electronic searches of Medline (1946-2015) 
      and Embase (1947-2015) to identify published studies using formula total diet 
      replacement diets (VLCD/LELD). Random effects meta-analysis using weighted mean 
      difference (WMD) in body weight between groups (with and without diabetes) as the 
      summary estimate. RESULTS: Final weight loss, in the five included studies, 
      weighted for study sizes, (n=569, mean BMI=35.5-42.6 kg/m(2)), was not 
      significantly different between participants with and without T2DM: -1.2 kg; 95% 
      CI: -4.1 to 1.6 kg). Rates of weight loss were also similar in the two groups 
      -0.6 kg per week (T2DM) and 0.5 kg per week (no diabetes), and for VLCD 
      (<800 kcal per day) and LELD (>800 kcal per day). CONCLUSIONS: Weight losses with 
      liquid-formula diets are very similar for VLCD and LELD and for obese subjects 
      with or without T2DM. They can potentially achieve new weight loss/ maintenance 
      targets of >15-20% for people with severe and medically complicated obesity.
FAU - Leslie, W S
AU  - Leslie WS
AD  - Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, 
      Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
FAU - Taylor, R
AU  - Taylor R
AD  - Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, 
      Newcastle Upon Tyne, UK.
FAU - Harris, L
AU  - Harris L
AD  - Institute of Mental Health & Wellbeing, College of Medical Veterinary and Life 
      Sciences, University of Glasgow, Glasgow, UK.
FAU - Lean, M E J
AU  - Lean ME
AD  - Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, 
      Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20151004
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
SB  - IM
EIN - Int J Obes (Lond). 2017 Jun;41(6):997. PMID: 28290463
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*complications/*diet therapy/prevention & control
MH  - *Diet, Reducing
MH  - Energy Intake/*physiology
MH  - Humans
MH  - Obesity/*complications/*diet therapy/prevention & control
MH  - Practice Guidelines as Topic
MH  - Time Factors
MH  - Weight Loss/*physiology
PMC - PMC5368342
COIS- WSL, MEJL and RT are currently engaged on the Diabetes Remission Clinical Trial 
      (DiRECT) funded by Diabetes UK with additional support in kind from Cambridge 
      Weight Plan. MEJL and RT have received support related to the use of formula diet 
      products from Cambridge Weight Plan and from Nestle.
EDAT- 2016/10/05 06:00
MHDA- 2018/02/17 06:00
PMCR- 2017/03/28
CRDT- 2016/10/05 06:00
PHST- 2016/03/24 00:00 [received]
PHST- 2016/09/14 00:00 [revised]
PHST- 2016/09/15 00:00 [accepted]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2018/02/17 06:00 [medline]
PHST- 2016/10/05 06:00 [entrez]
PHST- 2017/03/28 00:00 [pmc-release]
AID - ijo2016175 [pii]
AID - 10.1038/ijo.2016.175 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2017 Jan;41(1):96-101. doi: 10.1038/ijo.2016.175. Epub 2015 
      Oct 4.